Figure 6.

Non-bonded energy determination of the P2X4R in different states. Numbers indicate the changes in non-bonded energies, expressed as kcal/mol, of the whole wtP2X4R (ΔE_protein) in the different conformational complexes of the P2X4R. The rectangles indicate P2X4R states in the apo or holo state alone or following allosteric modulator binding. The arrows refer to the transition between the different states. The thicker blue lines indicate the favored P2X4R transitions after allosteric modulator binding.