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. 2017 Dec 15;8:918. doi: 10.3389/fphar.2017.00918

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Copyright © 2017 Latapiat, Rodríguez, Godoy, Montenegro, Barrera and Huidobro-Toro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of Zn(II) modulator activity in the C132A P2X4R mutant but not the C126A mutant. (A) Representative recordings of 1 μM ATP-gated currents in two P2X4R mutants (C132A and C126A) in the absence or presence of 10 μM Zn(II), 3 μM IVM and joint application of Zn(II) plus IVM. ATP and IVM applications are represented by blue and brown rectangles, respectively. Each set of recordings is derived from a single oocyte expressing either the C132A or the C126A mutants. (B) Statistical analyses of a set of 5 separate oocytes expressing the C132A mutant (open bars) and 4 oocytes expressing the C126A mutant (closed bars) (***p < 0.001); ns (not statistically significant).