Table 1.
Receptor | Sequence | |
---|---|---|
TM1 | 42 46 50 | |
ratP2X4R | 28VGLMNRAVQLLILAVIGVFVEKGY54 | |
ratP2X2R | 28LGFVHRMVQLLILLFVWVFIVQKSY54 | |
ratP2X7R | 28YGTIKILHMTFSVS-ALMSDKLY53 | |
TM2 | 336 341 349 | |
ratP2X4R | 331IIPTIVGLALVTVLCDVVL358 | |
ratP2X2R | 331LIPTILALTSVGSLCDLL358 | |
ratP2X7R | 331IIQLVIGLSLTVCIDLIN358 |
Key amino acids previously reported to participate in P2X4R IVM modulation are written in red, showing the coincidence with the present residues obtained by molecular docking (gray boxes). The corresponding residues in P2X2R and P2X7R, enumerated from the alignment with the P2XR sequence, are shown in orange.