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. 2016 Dec 14;1(3):184–192. doi: 10.1182/bloodadvances.2016000497

Figure 4.

Figure 4.

The effect of tasquinimod on granuloma formation. The effect of tasquinimod (TasQ) on granuloma formation was evaluated using the guinea pig granuloma model. (A) Lung sections derived from TasQ-treated (right panel) and mock-treated (left panel) guinea pigs were stained with hematoxylin and eosin, and representative micrographs obtained from 2 independent experiments are shown. Scale bars, 1 mm. (B) Granulomas with a diameter of >200 μm were counted for 3 animals in each group. Numbers of granulomas per section are shown as the mean ± standard error of the mean. *P < .01. (C) Lung sections derived from TasQ-treated and mock-treated guinea pigs were labeled with G213 mAb, and HRP-DAB-based detection was performed. Representative micrographs obtained from 2 independent experiments are presented with granulomas containing the central accumulation of S100A9+ neutrophils indicated with arrows. Scale bars, 500 μm. (D) Granulomas with S100A9+ neutrophil cores were counted per section for 3 animals in each group, and data are shown as the mean ± standard error of the mean. *P < .01.