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Expression of antigens in B-cell lineage ALL for potential antibody therapy
| Surface antigen | ALL subtype | Expression (%) | MoAb |
|---|---|---|---|
| CD20 | Mature B-cell precursor |
86-100 30-40 |
Rituximab, ofatumumab, obinituzumab |
| CD19 | Mature B-cell precursor |
95-<100 95-<100 |
Blinatumomab |
| CD22 | Mature B-cell precursor |
∼100 93-98 |
Inotuzumab ozogamicin, epratuzumab, moxetumomab pasudotox |
Adapted from Jabbour et al.2
