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. 2017 Jun 22;163(6):856–865. doi: 10.1099/mic.0.000478

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© 2017 The Authors

This is an open access article under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Fig. 2. — Analysis of the role of CDR11 and QDR1, encoding putative drug efflux pumps, in fluconazole resistance. (a) RNA-Seq expression of select SC5314 and P60002 transcripts. P60002 overexpressed three genes implicated in fluconazole resistance relative to SC5314: UPC2, CDR11 and QDR1. (b) Ectopic expression of the P60002 alleles of CDR11 and QDR1 in SC5314 increased transcript levels to a similar extent to those present in P60002. (c) Analysis of drug resistance in SC5314 strains ectopically expressing P60002 alleles of CDR11 or QDR1. Cells were plated onto YPD and allowed to grow in the presence of a 25 µg fluconazole disc. Plates were photographed after 2 days. (d) Quantitative analysis of fluconazole resistance in SC5314, P60002 or SC5314-derived strains expressing P60002 alleles of CDR11 and QDR1.