Figure 9.
Summary of nucleolus size with respect to crosslinking parameters. Radius of gyration, Rg, for each of the parameter values investigated in this study. For single nucleolus dynamics the values for ton are 0.09, 0.9 and 90 s. For split nucleolus dynamics ton = 0.09 and 90 s. Increase in ‘on’ time leads to an increase in the nucleolus size. Similarly, increase in the fraction of beads that are active outside the nucleolus (stride) increases the size of the nucleolus. For slow kinetics and comparable number of active beads inside and outside the nucleolus (light blue), there is little difference with respect to the case where no crosslinks are included (black). All dynamic crosslinking simulations have Keq = 9.