Table 1.
Patient demographics and baseline disease characteristics
| Variable | Pediatrics N = 60 | Adults N = 16 |
|---|---|---|
| Age, y, median (range) | 12 (2–17) | 34 (18–66) |
| ≤10 y | 23 (38.3%) | 0 |
| >10 y | 37 (61.7) | 16 (100%) |
| Body surface area, m2, median (range) | 1.2 (0.6–2.7) | 1.8 (1.1–2.7) |
| Sex, n (%) | ||
| Male | 37 (61.7) | 7 (43.8) |
| Female | 23 (38.3) | 9 (56.3) |
| Race | ||
| Caucasian | 45 (75) | 14 (87.5) |
| Asian | 4 (6.7) | 1 (6.3) |
| Black | 4 (6.7) | 0 |
| Other or missing (not specified) | 7 (11.7) | 1 (6.3) |
| Karnofsky statusa / Lansky Play score, n (%) | 37 (62) / 23 (38) | 16 (100) / NA |
| 100 | 15 (25) / 11 (18.3) | 0 / NA |
| 90 | 6 (10) / 6 (10) | 8 (50) / NA |
| 80 | 7 (11.7) / 4 (6.7) | 5 (31.3) / NA |
| 70 | 3 (5) / 2 (3.3) | 1 (6.3) / NA |
| <70 | 5 (8) / 0 | 2 (12.5) / NA |
| Histology/cytology, n (%) | ||
| Medulloblastoma | 39 (65) | 16 (100) |
| Glioblastoma multiforme | 5 (8.3) | 0 |
| Osteosarcoma | 5 (8.3) | 0 |
| Rhabdomyosarcoma | 4 (6.8) | 0 |
| Neuroblastoma | 3 (5.0) | 0 |
| Hepatoblastoma | 1 (1.7) | 0 |
| Anaplastic astrocytoma | 1 (1.7) | 0 |
| Oligoastrocytoma | 1 (1.7) | 0 |
| Gliomatosis | 1 (1.7) | 0 |
| Time, mo, from initial diagnosis of primary site to start of study, median (range), n = 60 | 35.63 (8.6–111.6) | 70.72 (15.9–210.9) |
| Time, mo, since most recent relapse/recurrence to start of study, median (range), n = 60 | 0.94 (0.3–7.2) | 1.61 (0.2–20.7) |
| Prior therapy, n (%) | ||
| Surgery | 59 (98.3) | 16 (100) |
| Radiotherapy | 49 (81.7) | 16 (100) |
| Chemotherapy | 60 (100.0) | 15 (93.8) |
aKPS missing for 1 (1.7) patient.