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. 2017 Jun 16;45(14):8378–8391. doi: 10.1093/nar/gkx521

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — TEM images showing normal ultrastructure of bloodstream form for treated and untreated (drug free control) cells of Tb427-WT after incubation with compound 1 or compound 2 for either 3 h or 24 h. F = flagellum, FP = flagellum pocket, k = kinetoplast. Images were observed in a Tecnai T20 (FEI) at 200 kV. Irregular structures in the kinetoplast are shown with arrows and arrowheads, indicating kDNA damage.