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. 2017 Jun 16;45(14):8378–8391. doi: 10.1093/nar/gkx521

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — (A) SPR competition sensorgrams showing the inhibition of a fixed concentration (2 μM) of HMGA1a (Top left panel) and HMGB1 (top right panel) binding to dsDNA containing AATAAT_ATTATT oligonucleotide in the presence of increasing concentration of 2. Concentration range from 0.05 to 200 μM (for HMGA1a) and 0.05 to 400 μM (for HMGB1). (B) Inhibition curves and IC₅₀ values for inhibition of binding of HMGA1a (lower left panel) and HMGB1 (lower right panel) to dsDNA by compound 2.