. 2017 Jun 16;45(14):8378–8391. doi: 10.1093/nar/gkx521

Table 1. Activity of compounds 1 and 2 against T. brucei 427WT and the isometamidium-resistant strain ISMR1.

Compounds	T. b. brucei 427WT	T. b. brucei ISMR1	Resistance Factor vs. Tb247WT
	EC₅₀ (μM) ± SEM	EC₅₀ (μM) ± SEM
1	0.83 ± 0.08^a	105.3 ± 3.2	127 ***
2	0. 220 ± 0.002^a	29.0 ± 0.7	132 ***
Isometamidium	0.016 ± 0.001	1464 ± 94	92522 ***

EC₅₀ values are given as mean of at least three independent determinations and SEM. The resistance factor (RF) is the ratio of the EC₅₀ values of the adapted strain and the wild-type control. Statistical significance was determined using a two-tailed unpaired t-test.

^aReference (3). Asterisks represent P-values for statistically significant resistance, as calculated using a two-tailed unpaired Student's t-test: ***, P-value <0.0001.