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. 2017 Jul 20;20(10):844–854. doi: 10.1093/ijnp/pyx058

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© The Author 2017. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — (A) Active lever presses during self-administration. (B) Cocaine intake (mg/kg) during self-administration. Females took more cocaine than males on days 1 and 2 (*P<.05). (C) During extinction, active lever presses significantly decreased compared with day 1 on all ensuing days (#P<.05). (D) Active lever presses during cued reinstatement. Rats robustly responded on the cue-associated lever in the Cue+Veh condition relative to extinction (Ext) and Cue+Oxy. Significant difference between test conditions (*P<.05).