Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 21;45(19):11121–11130. doi: 10.1093/nar/gkx728

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 4. — Repression of SGK1 transcription increases with GRcXR DNA residence time. (A) Normalized mean number of SGK1 mRNA molecules as function of DNA residence time in wild-type U2-OS cells as control (ctrl) and U2-OS cells expressing GRcXR (spheres, 308/304, 308/294, 296/316, 267/274, 167/157, 270/211 and 290/283 cells). Error bars denote s.e.m. (B) Normalized burst frequency of SGK1 transcription as function of GRcXR DNA residence time. Cell numbers are as in (A). (C) Normalized burst size of SGK1 transcription as function of GRcXR DNA residence time (70/19, 51/28, 53/29, 69/34, 22/7, 31/12 and 42/20 nascent sites). Error bars denote s.e.m. Lines are calculated based on a model in which the on-rate constant of a two-state gene transcription model is a function of GRcXR DNA residence time (continuous lines) or in which both the on-rate constant and the transcription rate constant are a function of GRcXR DNA residence time (dashed lines).