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. 2017 Aug 21;45(19):11121–11130. doi: 10.1093/nar/gkx728

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Rate constants of the two-state model of SGK1 transcription. On-rate constant (squares), off-rate constant (triangles) and transcription rate constant (spheres) were calculated from the measured values of mean SGK1 mRNA, burst frequency and burst size (Figure 4A–C), refer to one allele, are normalized to the SGK1 degradation rate constant and are plotted as function of GRcXR DNA residence time (ctrl denotes wild-type U2-OS cells without GRcXR expression) (Supplementary Information). Error bars denote s.e.m. Lines are fits based on a model in which the on-rate constant is a function of GRcXR DNA residence time (Equation (12) in Supplementary Information, reduced ) and off-rate and transcription rate are constant with respect to GRcXR DNA residence time (continuous lines) or a global fit in which both the on-rate constant and the transcription rate constant are a function of GRcXR DNA residence time (Equations (12) and (13) in Supplementary Information, reduced ) and the off-rate is constant with respect to GRcXR DNA residence time (dashed line).

Inline graphic — Rate constants of the two-state model of SGK1 transcription. On-rate constant (squares), off-rate constant (triangles) and transcription rate constant (spheres) were calculated from the measured values of mean SGK1 mRNA, burst frequency and burst size (Figure 4A–C), refer to one allele, are normalized to the SGK1 degradation rate constant and are plotted as function of GRcXR DNA residence time (ctrl denotes wild-type U2-OS cells without GRcXR expression) (Supplementary Information). Error bars denote s.e.m. Lines are fits based on a model in which the on-rate constant is a function of GRcXR DNA residence time (Equation (12) in Supplementary Information, reduced ) and off-rate and transcription rate are constant with respect to GRcXR DNA residence time (continuous lines) or a global fit in which both the on-rate constant and the transcription rate constant are a function of GRcXR DNA residence time (Equations (12) and (13) in Supplementary Information, reduced ) and the off-rate is constant with respect to GRcXR DNA residence time (dashed line).