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. 2017 Aug 21;45(19):11121–11130. doi: 10.1093/nar/gkx728

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Model of SGK1 transcription repression by TALE-TF constructs. TALE-TF binds to and unbinds from the GRE of SGK1 with rate constants and competitive to endogenous GR. If TALE-TF is bound, it prevents gene activation by competitive inhibition of GR DNA binding, and the gene assumes a blocked state (left shade) in addition to the ‘off’- and ‘on’-states of the two-state model of gene transcription (right shade). : rate constant of SGK1 activation, : rate constant of SGK1 deactivation, : transcription rate constant of SGK1, : degradation rate constant of SGK1. Cartoons illustrate the different states of the extended two-state model.

Inline graphic — Model of SGK1 transcription repression by TALE-TF constructs. TALE-TF binds to and unbinds from the GRE of SGK1 with rate constants and competitive to endogenous GR. If TALE-TF is bound, it prevents gene activation by competitive inhibition of GR DNA binding, and the gene assumes a blocked state (left shade) in addition to the ‘off’- and ‘on’-states of the two-state model of gene transcription (right shade). : rate constant of SGK1 activation, : rate constant of SGK1 deactivation, : transcription rate constant of SGK1, : degradation rate constant of SGK1. Cartoons illustrate the different states of the extended two-state model.