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Type I errors in the absence of differential expression means. There are n samples of cases and controls each and varying proportions of excess zeros s. The MDSeq controls type I errors well at moderate to large sample sizes. DESeq2 and edgeR methods may be conservative under the presence of excess zeros s > 0. Results are based on 1,000 simulations without additional covariates. Reference lines (in red) are drawn at the 0.05 error rate.
