Table 3.

Multivariate Group Discrimination

	All High Risk Offspring Vs CcO			SzO Vs CcO			BpO Vs CcO			SzO Vs BpO
	OR [95% CI]	t	P	OR [95% CI]	t	P	OR [95% CI]	t	P	OR [95% CI]	t	P
Obstetric complications	2.8 [1.4–5.5]	2.9	.004	3.2 [1.3–8.5]	2.4	.017	2.4 [1.1–5.1]	2.2	.028
Neurological soft signs	1.2 [1.1–1.3]	4.6	<.001	1.2 [1.1–1.3]	3.9	<.001	1.2 [1.1–1.3]	3.6	<.001
General intelligence				0.92 [0.88–0.96]	−3.6	<.001				0.92 [0.89–0.96]	−4.4	<.001
Total grey matter volume	0.98 [0.95–0.99]	−2.0	.043

Note: SzO, offspring of probands with schizophrenia; BpO, offspring of probands with bipolar disorder; CcO, offspring of community controls; OR, odds ratio; CI, confidence interval. Binary logistic regression models including family and site as random variables adjusted for age, sex, and total intracraneal volume (for grey matter volume) where significant.