| PARG |
|
Nucleus, cytoplasm, mitochondria |
Macro domain |
PAR chain, exo- and endo-glycohydrolysis to produce ADP-ribose and short PAR chain. |
(179,180) |
| TARG1 |
C6orf130 OARD1 |
Nucleus, cytoplasm |
Macro domain |
Mono ADP-ribosylated protein, cleaving the bond between acidic residues and ADP-ribose; poly ADP-ribosylated protein, releasing the whole PAR chain from protein; deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose, and O-butyryl-ADP-ribose to produce ADP-ribose and acetate, propionate, and butyrate, respectively. |
(125,130,181) |
| MacroD1 |
LRP16 |
Nucleus |
Macro domain |
Mono ADP-ribosylated protein, cleaving the bond between acidic residues and ADP-ribose; deacetylation of O-acetyl-ADP-ribose. |
(130) |
| MacroD2 |
C20orf133 |
Nucleus, cytoplasm |
Macro domain |
Mono ADP-ribosylated protein, cleaving the bond between acidic residues and ADP-ribose; deacetylation of O-acetyl-ADP-ribose. |
(130) |
| ADPRH |
ARH1 |
Nucleus, cytoplasm |
|
Mono ADP-ribose-arginine protein, cleaving the N-glycosidic bond of ADP-ribose attached to an Arg residue of a protein to produce free ADP-ribose and unmodified protein. |
(131) |
| ADPRHL2 |
ARH3 |
Nucleus, cytoplasm, mitochondria |
|
Deacetylation of O-acetyl-ADP-ribose; PAR chain, exo-glycohydrolysis to produce ADP-ribose. |
(126,182,183) |
| NUDT9 |
|
Cytoplasm |
Nudix hydrolase |
Cleaving ADP-ribose and IDP-ribose to form the corresponding nucleoside 5′-monophosphates and ribose 5-phosphate; cleaving O-acetyl-ADP-ribose to form AMP and acetylated ribose 5′-phosphate; low activity to digest PAR by cleaving the pyrophosphate bonds. |
(127,128,184) |
| NUDT16 |
|
Nucleus, cytoplasm |
Nudix hydrolase |
Cleaving m7G or m227G caps from U8 snoRNA or mRNA and leaving a 5′-monophosphate-RNA; Poly/mono ADP-ribosylated protein, cleaving the pyrophosphate bonds of ADP-ribose. |
(128,185) |
| ENPP1 |
|
Extracellular, lysosome, plasma membrane |
|
Cleaving the phosphodiester bonds in (d)NTP, (d)NDP, NAD, ADP-ribose, FAD, diadenosine polyphosphates, UDP sugars, PAR chains and mono ADP-ribosylated proteins. |
(129) |
