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Structural mechanism of the redox regulation of FosB/JunD through coupled DNA-binding and structure transition. FJoxi (type I) is superimposed onto FJ-DNA (type I) by matching the JunD molecules, respectively. Two views separated by 170° are shown. Insets show a zoomed-in view of the DNA-binding consensus motifs of JunD (Motif-J) and FosB (Motif-F), depicting the redox switch ‘OFF’ and ‘ON’ states. Dashed lines indicate conformational changes. Color scheme is indicated in the key.
