Table 1. Positive selection statistics.
| Description | Value | Other |
|---|---|---|
| Species investigated | 9 | Human, chimpanzee, gorilla, orangutan, gibbon, macaque, baboon, vervet, marmoset |
| One-to-one ortholog clusters analyzed for positive selection | 11,096 | 50% of human protein-coding genes; 6.6 × 106 codons human; 5.7 × 107 codons total |
| Overall dN/dS rate (across 11 096 clusters) | 0.21 | d N = 0.0477, dS = 0.2235 |
| Positively selected genes (PSG) a | 331 | 3% of genes tested |
| Positively selected residues (PSR) | 934 | 0.5% of 1.9 × 105 PSG codons; 0.014% of 6.6 × 106 tested human codons |
| PSG dN/dS rate b | 6.85 (median) | 2.10 (minimum) |
aGenes for which across all four evolutionary models tested: (i) the selection model gives a significantly better fit than the neutral model and (ii) that contain at least one significant PSR (Materials and Methods).
bCalculated from the per-PSG averages of the dN/dS rates estimated in the four evolutionary models tested (Materials and Methods).