Table 2. Positively selected processes and gene families.

Biological process or gene family	Selected genesa
Pattern recognition & defense pathways	TLR1/8, MAVS, IFI16, CASP10, TRIM5, OAS1, RNASEL, PGLYRP1, NLRP11, CLEC1A/4A
Cytokines & receptors	IL3/13/25, IL4R, CXCR/R2/L16, CCRL2, CASP1
Immunological (marker) molecules	20 CD genes; CD4/5/1C/48/58/…, CD22 [SIGLEC2], CD33 [SIGLEC3], CD33L [SIGLEC6], HLA-DPA1
Complement system	C5/8B/9, CR2, CFH, CD46/55/59
Antimicrobial functions & cytotoxic activities	TF, LTF, DEFB1/118/132/136, GZMA/B/K, PRG2/3
Reproduction & testes-linked genes	TEX11/26/29, CATSPER1/3/G, SHBG, SPACA7, CYLC1/2, CT55, PATE1, SPATA18/32
Chromosome segregation & centromeres	CENPO/T, CEP250, PCNT, REC8, SGOL2, MISP, CDK5RAP2, KIAA1328 [Hinderin]
Smell & taste genes	OR10Q1/G7/D3, BPIFB3, TAS2R10/20/41
Ion channels	SLC6A16/9C1/26A3/44A2, CLCA1/4, SCNN1D/7A/11A
Mitochondrial proteins	19 genes; NDUFA10, COA1, MRPS30, MTIF3, TMEM126A/B, LRPPRC, TFB2M, …
Other	KRTAP24-1, HDAC1, APOD/L6/BR, PARP9/13/14
Uncharacterized genes	CCDC27/57, KIAA1328/0226-like/1407, PRR14/30, SSMEM1, SUN5, TMEM186/215/225, MFSD7, FAM162A/220A, RNF213, TSPAN8, LUZP4, MS4A12, CMTM6, C5orf45, C3orf17, C12orf76, C1orf168, C20orf96, CXorf66, …

^aSee Supplementary Table S4 for the complete list of PSG.