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. 2017 May 30;45(14):e129. doi: 10.1093/nar/gkx492

Figure 7.

Figure 7.

The predicted influence of ELAVL1 binding on the repression effect of miRNA miR-331-3p. (A) An illustrative model of the co-binding of RBP ELAVL1 and miRNA miR-331-3p on the 3′ UTR of gene ERBB2. miR-331b represents the binding region of miRNA miR-331-3p. The width of the arrow represents the relative strength of miR-331-3p binding. (B) The change of the predicted binding scores corresponded to the shift of ELAVL1 binding sites from the wild-type to the URE mutant on the 3′ UTR of gene ERBB2. The bottom shows the locations of URE and miR-331b regions, mutation positions in the URE region, mutation positions in the miR-331b region, mutation positions in both URE and miR-331b regions, and the experimentally detected shift of ELAVL1 binding resulting from the URE mutant, respectively. All mutation sites are represented by the inverted triangles. Abbreviation: WT, wild-type; MT, mutant; URE, U-rich element.