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. 2017 Sep 13;45(19):11268–11280. doi: 10.1093/nar/gkx823

Figure 1.

Figure 1.

(A) Bar graph represents percentage of full-length sequences with and without a putative quadruplex sequence (PQS) among HBV genotypes (GTs). The number of full length sequences analysed is given in parentheses. (B) Schematic representation of the position of the putative G-quadruplex motif (blue) in the promoter region of pres2/S gene. The red line with an arrow head represents preS1 CDS and the yellow line within the red line with an arrow head represent preS2/S CDS. All lines are drawn to scale using DNA plotter. (C) A schematic showing the position of the G-quadruplex motif with respect to the transcription start site (TSS). (D) Schematic representation showing conservation of Gs which are involved in the formation of the G-tetrads within the G-quadruplex structure. Each coloured box represents conservation of a G residue in the PQS sequence within each genotype (GT). The height of the box represents percentage of sequences having a G residue at that particular position (in aligned sequences). For example, if the height is half of the maximum height, 50% of the sequences have a G residue at that position. Representative sequences of the PQS region from each genotype are given below. The number of sequences analysed is given in parentheses.