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. 2017 Sep 13;45(19):11268–11280. doi: 10.1093/nar/gkx823

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — (A) CD spectra showing the formation of a G-quadruplex structure in genotype B wild-type PQS (GTB-WT-PQS) oligonucleotide. The mutated oligonucleotide (GTB-MUT-PQS) does not form a G-quadruplex structure. A ssDNA control (25mer) incapable of forming a G-quadruplex is taken as a negative control. (B) ¹H NMR spectra of genotype B wild type (GTB-WT-PQS) and mutated (GTB-MUT-PQS) PQS oligonucleotide. Please see Supplementary File S3 Table S1 for sequence of the oligonucleotides.