Figure 7.

The impairment of ribosome biogenesis changes the general expression pattern of the ribosome-related genes. (A) Hierarchical clustering of the changes in the mRNA levels upon single gene deletions (top list) on the significantly changing genes in the different functional categories of ribosome-related genes (right). The RRB regulon, split into four subclusters, is represented on the left (Subcluster I in red and Subcluster II in blue). The fold change of the mRNA expression in the mutant versus the corresponding wild type is indicated by the colour bar as log₂ values. (B) Distribution of pre-60S and the combination of the 90S and pre-40S factors between the two main subclusters of RBB genes. (C) Venn diagrams showing the balanced (Subcluster I) and biased (Subcluster II) presence of PAC and RRPE elements in the two main subclusters within the RBB group. P-values correspond to the Chi-square test.