Fig. 1.

—Putative central peroxin factors for PTS1- and PTS2-mediated peroxisomal matrix protein import in Toxoplasma gondii. Pex5, Pex7, and Pex14 possess all the required motifs for proper function/interaction during peroxisomal matrix protein import. Numbers indicate amino acid positions of the individual primary sequences. Cys: cysteine; N-t motif: conserved N-terminal motif of Pex5; FxxxW and WxxxF/Y: motifs for interaction of Pex5 with Pex13 and Pex14; Pex7-binding domain: motif known to be crucial for interaction of the co-receptor Pex5 with the PTS2 receptor Pex7; TPR: tetratricopeptide repeat, protein–protein interaction motif; WD40: protein–protein interaction motif; Pex14_N: N-terminal domain of Pex14 known to be required for interaction with the PTS1 receptor Pex5; PxxP: potential Pex13 binding motif of Pex14; PUB: PNGase/UBA or UBX domain.