. 2017 Nov 22;6:e26517. doi: 10.7554/eLife.26517

Table 1. Summary of all ion channel models and densities implemented in the mouse mature GC model.

Categorial values of the ion channel expression profiles: 0 = not existent or very weak, 1 = weak, 2 = moderate, 3 = strong. Conductances [^mS/_cm²] for each ion channel used in the model are given in the gray fields.

Name	Soma	Axon	AIS	GCL	IML	MML	OML	Reference	Ion channel model
Na_v 1.1 Na_v 1.2 Na_v 1.6	3 0	0 3	0 3	0 0	0 0	0 0	0 0	(Westenbroek et al., 1989; Schmidt-Hieber and Bischofberger, 2010)	8-state model from (Schmidt-Hieber and Bischofberger, 2010). Inact. modified according to (Rush et al., 2005; Schmidt-Hieber and Bischofberger, 2010) (see text)
	0	1	3	0	0	0	0	(Kress et al., 2010; Schmidt-Hieber and Bischofberger, 2010)
	88.128	88.1280	518.400	-	-	-	-
K2Ps (passive)	3	1	1	2	2	2	2	(Lesage et al., 1997; Hervieu et al., 2001; Talley et al., 2001; Gabriel et al., 2002; Aller and Wisden, 2008; Yarishkin et al., 2014)
K2Ps (passive)	0.014	0.007	0.007	0.014	0.014	0.014	0.014
Kir 2.x	3	1	1	2	2	2	2	(Karschin et al., 1996; Miyashita and Kubo, 1997; Stonehouse et al., 1999; Prüss et al., 2003)	6-state model, modification see Appendix 2.
Kir 2.x	0.1416	0.0674	0.0674	0.1416	0.1416	0.1416	0.1416		6-state model, modification see Appendix 2.
HCN1-3	0	0	0	0	2	2	2	(Notomi and Shigemoto, 2004)	2-state model, from (Stegen et al., 2012); activation −10 mV, added cAMP-sens. and slow comp. of act.
HCN1-3	-	-	-	-	0.004	0.004	0.004
K_v 1.1	0	3	3	0	0	0	0	(Rhodes et al., 1997; Grosse et al., 2000; Monaghan et al., 2001)	nh model from (Christie et al., 1989)
K_v 1.1	-	0.25	0.25	-	-	-	-		nh model from (Christie et al., 1989)
K_v 1.4	0	3	3	0	0	0	0	(Rhodes et al., 1997; Cooper et al., 1998; Grosse et al., 2000; Monaghan et al., 2001)	n⁴h model from (Wissmann et al., 2003)
K_v 1.4	-	1	1	-	-	-	-		n⁴h model from (Wissmann et al., 2003)
K_v 2.1	3	0	0	0	0	0	0	(Rhodes et al., 1997; Murakoshi and Trimmer, 1999)	mh model, fitted using (VanDongen et al., 1990; Kramer et al., 1998; Kerschensteiner and Stocker, 1999; McCrossan et al., 2003; Gordon et al., 2006)
K_v 2.1	7.09	-	-	-	-	-	-
K_v 3.3/3.4	0	2	3	0	0	0	0	(Weiser et al., 1994; Chang et al., 2007)	mh model, fitted using (Rudy et al., 1991; Schröter et al., 1991; Rettig et al., 1992; Miera et al., 1992; Riazanski et al., 2001; Desai et al., 2008)
K_v 3.3/3.4	-	7.6562	30.7813	-	-	-	-
K_v 4.2/3 +KChIP/DPP6	0	0	0	1	2	3	3	(Rhodes et al., 2004; Zagha et al., 2005; Menegola and Trimmer, 2006)	13-state model from (Barghaan et al., 2008); activation −20 mV according to (Barghaan et al., 2008; Figure S1A) and (Jerng et al., 1999; An et al., 2000; Bähring et al., 2001; Patel et al., 2004; Jerng et al., 2005; Rüschenschmidt et al., 2006; Kaulin et al., 2008; Kim et al., 2008)
K_v 4.2/3 +KChIP/DPP6	-	-	-	2.1750	4.35	4.35	4.35
K_v 7.2/3 (KCNQ2 and 3)	0	2	3	0	0	0	0	(Cooper et al., 2001; Klinger et al., 2011; Martinello et al., 2015)	mh model from (Mateos-Aparicio et al., 2014) (η = 0.5, see Tab. S1 in that publication)
K_v 7.2/3 (KCNQ2 and 3)	-	1.3400	6.7000	-	-	-	-
Ca_v 1.2 (L-type)	3	0	1	1	2	2	2	(Tippens et al., 2008; Leitch et al., 2009)	mh₁h₂ model from GENESIS (Evans et al., 2013), added Ca²⁺-dep. inactivation (h2)
Ca_v 1.2 (L-type)	0.0200	-	0.0100	0.0100	0.0400	0.0400	0.0400
Ca_v 1.3	3	1	2	1	2	2	2	(Tippens et al., 2008; Leitch et al., 2009)	mh₁h₂ model from GENESIS (Evans et al., 2013), added Ca²⁺-dep. inactivation, modified after (Bell et al., 2001; Koschak et al., 2001)
Ca_v 1.3	0.0160	0.0040	0.0080	0.0040	0.0080	0.0080	0.0080
Ca_v 2.1/2 (N-/P/Q-type)	3	2	2	1	1	1	1	(Day et al., 1996; Chung et al., 2001; Li et al., 2007; Xu et al., 2007; 2010)	m²h model from (Fox et al., 1987); set inact. time constant to 100 ms according to (Fox et al., 1987; Huang et al., 2010)
Ca_v 2.1/2 (N-/P/Q-type)	0.3000	0.0500	0.0500	0.0500	0.0500	0.0500	0.0500
Ca_v 3.2 (T-type)	3	1	1	2	2	2	2	(Craig et al., 1999; McKay et al., 2006; Martinello et al., 2015)	8-state model from (Burgess et al., 2002)
Ca_v 3.2 (T-type)	0.0220	0.0080	0.0080	0.0220	0.0220	0.0220	0.0220		8-state model from (Burgess et al., 2002)
BK (slo1) α αβ	2	3	3	0	0	0	0	(Knaus et al., 1996; Misonou et al., 2006; Sailer et al., 2006; Kaufmann et al., 2010)	Model from (Jaffe et al., 2011); modification see Appendix 2
BK (slo1) α αβ	15.6 3.9	62.4 15.6	62.4 15.6	-	-	-	-
SK2	0	2	3	0	1	1	1	(Obermair et al., 2003; Sailer et al., 2004; Maciaszek et al., 2012; Ballesteros-Merino et al., 2014)	Model from (Solinas et al., 2007) based on (Hirschberg et al., 1998; 1999)
SK2	0.001	0.013	0.083	0.002	0.004	0.004	0.004