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. 2017 May 12;45(13):7736–7750. doi: 10.1093/nar/gkx379

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Model for SPMMV pathogenicity based on P1 inhibition of target RNA binding by pre-assembled AGO1 complexes. P1 binding to AGO1 complexes loaded with SPMMV-derived vsiRNAs could inhibit SPMMV RNA targeting by preventing its association with pre-assembled AGO1 complxes. In addition, P1 binding to AGO1/miR403 complexes could prevent their association with AGO2 mRNA binding, leading to derepression of AGO2 mRNA. AGO2 would overaccumulate and load SPMMV vsiRNAs to target complementary SPMMV RNAs. For simplicity, P1 interaction with AGO2 is omitted in this model.