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. 2017 Jul 29;45(17):9837–9849. doi: 10.1093/nar/gkx680

Figure 2.

Figure 2.

pri-miRNA loci display complex patterns of distal TSS. (A) Distribution of pri-miRNA TSS log10 distance (in kb) relative to the miRNA precursor across all mature miRNA species is shown separately for intragenic (median distance 33.8 kb) and intergenic (median distance 20.4 kb) miRNA TSS, for miRNAs from miRBase and GENCODE. (B) Total numbers of intra- and intergenic pri-miRNA loci with one or multiple TSS elements found across all cell types (refer to Supplementary Table S3 listing miRNAs in each category), for miRNAs from miRBase and GENCODE. (C) GRO-seq signal across four cell types (ESC, HeLa, GM cells and HUVEC) at the complex pri-miRNA locus of hsa-mir-29a∼29b-1 cluster is shown (chr7:130 376 783–131 016 782). Four distinct TSS were identified, with the most distal (TSS4) being shared with the ncRNA LINC-PINT (FLJ43663).