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. 2017 Jul 29;45(18):10466–10480. doi: 10.1093/nar/gkx672

Table 1. Enrichment analysis of different categories of genes among Plagl1-regulated genes and genes with at least one Plagl1 binding site in Neuro-2a neuroblastoma cells.

DGE ChIP-seq
No. of ↓ among → Plagl1-regulated genes Expressed genes (12 861) P-value Genes with a Plagl1 binding site All UCSC genes (23 100) P-value
Plagl1-regulated genes 351 217 351 1 × 10−81
Genes with a Plagl1 binding site 217 3082 5.4 × 10−53 3859
Imprinted Genes 7 61 0.001 25 115 0.03
ECM genes 17 177 5.3 × 10−6 92 369 1 × 10−5
IGN members (4) 15 297 0.009 88 407 0.002
PLAG1 target genes (36) 10 41 9.8 × 10−8 24 57 4 × 10−6
Plagl2 target genes (37) 8 20 2.6 × 10−8 17 23 2 × 10−9
Plagl1 target genes (38) 4 85 ns 19 108 ns
Neuroblastoma signature genes (40) 2 54 ns 16 59 0.02

IGN, PLAG1-, Plagl2-, Plagl1-target genes and the human neuroblastoma signature genes are from the indicated references. P-values were calculated using the hypergeometric distribution. ns, not significant.