Table 1. Enrichment analysis of different categories of genes among Plagl1-regulated genes and genes with at least one Plagl1 binding site in Neuro-2a neuroblastoma cells.
| DGE | ChIP-seq | |||||
|---|---|---|---|---|---|---|
| No. of ↓ among → | Plagl1-regulated genes | Expressed genes (12 861) | P-value | Genes with a Plagl1 binding site | All UCSC genes (23 100) | P-value |
| Plagl1-regulated genes | 351 | 217 | 351 | 1 × 10−81 | ||
| Genes with a Plagl1 binding site | 217 | 3082 | 5.4 × 10−53 | 3859 | ||
| Imprinted Genes | 7 | 61 | 0.001 | 25 | 115 | 0.03 |
| ECM genes | 17 | 177 | 5.3 × 10−6 | 92 | 369 | 1 × 10−5 |
| IGN members (4) | 15 | 297 | 0.009 | 88 | 407 | 0.002 |
| PLAG1 target genes (36) | 10 | 41 | 9.8 × 10−8 | 24 | 57 | 4 × 10−6 |
| Plagl2 target genes (37) | 8 | 20 | 2.6 × 10−8 | 17 | 23 | 2 × 10−9 |
| Plagl1 target genes (38) | 4 | 85 | ns | 19 | 108 | ns |
| Neuroblastoma signature genes (40) | 2 | 54 | ns | 16 | 59 | 0.02 |
IGN, PLAG1-, Plagl2-, Plagl1-target genes and the human neuroblastoma signature genes are from the indicated references. P-values were calculated using the hypergeometric distribution. ns, not significant.