Table 2. Enrichment analysis of different categories of genes among genes differentially expressed in wild-type versus Plagl1+/-pat. mouse embryonic fibroblasts. P-values were calculated using the hypergeometric distribution.
| Day 2 (proliferation) | Day 8 (confluence) | Day 10 (quiescence) | Day 12 (quiescence) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of ↓ among → | Genes called DE | Expressed genes (15 346) | P-value | Genes called DE | Expressed genes (15 945) | P-value | Genes called DE | Expressed genes (15 998) | P-value | Genes called DE | Expressed genes (15 788) | P-value |
| Genes called DE (down/up) | 29 (19/10) | 32 (6/26) | 183 (117/66) | 9 (3/6) | ||||||||
| IGN members | 5 | 383 | 6 × 10−4 | 8 | 387 | 6 × 10−7 | 20 | 390 | 2 × 10−8 | 3 | 384 | 1 × 10−3 |
| Imprinted genes | 0 | 101 | - | 2 | 106 | 2 × 10−2 | 7 | 107 | 2 × 10−4 | 2 | 108 | 1 × 10−3 |
| Plagl1-regulated genes in Neuro-2a cells | 1 | 269 | 3 × 10−1 | 1 | 291 | 3 × 10−1 | 4 | 295 | 2 × 10−1 | 1 | 281 | 1 × 10−1 |
| Genes with 1+ Plagl1 binding site in Neuro-2a cells | 5 | 3133 | 2 × 10−1 | 2 | 3234 | 3 × 10−2 | 31 | 3266 | 4 × 10−2 | 3 | 3266 | 2 × 10−1 |
| Plagl1-regulated genes in Min6 cells | 0 | 329 | - | 0 | 351 | - | 4 | 358 | 2 × 10−1 | 0 | 360 | 8 × 10−1 |