Table 1.
Sequence and Structure Similarity Profile of Protein Sequences Comprising Each Enzymatic Activity Assigned to the Bona Fide (+) Data Set of Intragenomic Analogous Enzymes
| EC | Gene | UniprotKB | PDB | Cluster | Gene | UniprotKB | PDB | Cluster | Identity (%) | Similarity (%) | Score | TM-Score | RMSD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1.3.1.20 | DHDH | Q9UQ10 | 2O48a | 1 | AKR1C2 | P52895 | 2HDJ | 2 | 16.3 | 28.0 | 40.0 | 0.34186 | 6.09 |
| DHDH | Q9UQ10 | 2O48a | 1 | AKR1C1 | Q04828 | 1J96 | 2 | 16.0 | 27.5 | 33.0 | 0.33888 | 5.89 | |
| AKR1C2 | P52895 | 2HDJ | 2 | AKR1C1 | Q04828 | 1J96 | 2 | 97.8 | 98.5 | 1662.0 | 0.99487 | 0.40 | |
| 1.15.1.1 | SOD2 | P04179 | 1LUV | 1 | SOD1 | P00441 | 4XCR | 2 | 13.6 | 24.8 | 37.5 | 0.24203 | 4.48 |
| SOD2 | P04179 | 1LUV | 1 | SOD3 | P08294 | 2JLP | 2 | 3.7 | 6.7 | 21.5 | 0.28352 | 5.09 | |
| SOD1 | P00441 | 4XCR | 2 | SOD3 | P08294 | 2JLP | 2 | 25.1 | 34.4 | 265.5 | 0.70353 | 1.76 | |
| 2.4.1.22 | B4GALT2 | O60909 | ND | 1 | B4GALT1 | P15291 | 2AH9 | 1 | 50.0 | 62.7 | 1049.5 | ND | ND |
| B4GALT2 | O60909 | ND | 1 | LALBA | P00709 | 3B0O | 2 | 4.0 | 7.0 | 7.5 | ND | ND | |
| B4GALT1 | P15291 | 2AH9 | 1 | LALBA | P00709 | 3B0O | 2 | 6.8 | 12.0 | 9.0 | 0.23387 | 5.70 | |
| 2.4.2.31 | SIRT6 | Q8N6T7 | 3K35 | 1 | ART1 | P52961 | ND | 2 | 15.4 | 23.7 | 30.5 | ND | ND |
| SIRT6 | Q8N6T7 | 3K35 | 1 | ART3 | Q13508 | ND | 2 | 18.6 | 27.2 | 43.5 | ND | ND | |
| SIRT6 | Q8N6T7 | 3K35 | 1 | ART4 | Q93070 | ND | 2 | 2.1 | 3.2 | 17.5 | ND | ND | |
| SIRT6 | Q8N6T7 | 3K35 | 1 | ART5 | Q96L15 | ND | 2 | 4.3 | 5.7 | 15.5 | ND | ND | |
| ART1 | P52961 | ND | 2 | ART3 | Q13508 | ND | 2 | 21.7 | 33.0 | 263.5 | ND | ND | |
| ART1 | P52961 | ND | 2 | ART4 | Q93070 | ND | 2 | 29.3 | 42.7 | 377.0 | ND | ND | |
| ART1 | P52961 | ND | 2 | ART5 | Q96L15 | ND | 2 | 34.8 | 46.6 | 447.5 | ND | ND | |
| ART3 | Q13508 | ND | 2 | ART4 | Q93070 | ND | 2 | 18.8 | 30.5 | 221.0 | ND | ND | |
| ART3 | Q13508 | ND | 2 | ART5 | Q96L15 | ND | 2 | 25.6 | 35.1 | 391.5 | ND | ND | |
| ART4 | Q93070 | ND | 2 | ART5 | Q96L15 | ND | 2 | 28.7 | 43.9 | 321.0 | ND | ND | |
| 2.7.1.67 | PI4KA | P42356 | ND | 1 | PI4KB | Q9UBF8 | 4WAE | 1 | 10.8 | 17.1 | 527.5 | ND | ND |
| PI4KA | P42356 | ND | 1 | PI4K2A | Q9BTU6 | 4HND | 2 | 3.8 | 6.4 | 46.0 | ND | ND | |
| PI4KA | P42356 | ND | 1 | PI4K2B | Q8TCG2 | 4WTV | 2 | 4.7 | 8.0 | 28.5 | ND | ND | |
| PI4KB | Q9UBF8 | 4WAE | 1 | PI4K2A | Q9BTU6 | 4HND | 2 | 9.8 | 16.4 | 45.5 | 0.48577 | 4.85 | |
| PI4KB | Q9UBF8 | 4WAE | 1 | PI4K2B | Q8TCG2 | 4WTV | 2 | 9.9 | 16.5 | 51.0 | 0.31144 | 4.58 | |
| PI4K2A | Q9BTU6 | 4HND | 2 | PI4K2B | Q8TCG2 | 4WTV | 2 | 57.7 | 69.5 | 1472.5 | 0.46188 | 1.74 | |
| 2.7.4.21 | PPIP5K2 | O43314 | 3T9A | 1 | PPIP5K1 | Q6PFW1 | ND | 1 | 56.2 | 64.5 | 4170.5 | ND | ND |
| PPIP5K2 | O43314 | 3T9A | 1 | IP6K1 | Q92551 | ND | 2 | 8.0 | 12.8 | 50.0 | ND | ND | |
| PPIP5K2 | O43314 | 3T9A | 1 | IP6K3 | Q96PC2 | ND | 2 | 7.1 | 11.2 | 49.5 | ND | ND | |
| PPIP5K2 | O43314 | 3T9A | 1 | IP6K2 | Q9UHH9 | ND | 2 | 7.0 | 11.3 | 47.5 | ND | ND | |
| PPIP5K1 | Q6PFW1 | ND | 1 | IP6K1 | Q92551 | ND | 2 | 6.7 | 10.5 | 96.5 | ND | ND | |
| PPIP5K1 | Q6PFW1 | ND | 1 | IP6K3 | Q96PC2 | ND | 2 | 5.8 | 10.2 | 42.5 | ND | ND | |
| PPIP5K1 | Q6PFW1 | ND | 1 | IP6K2 | Q9UHH9 | ND | 2 | 6.1 | 9.6 | 43.5 | ND | ND | |
| IP6K1 | Q92551 | ND | 2 | IP6K3 | Q96PC2 | ND | 2 | 47.6 | 61.4 | 1072.0 | ND | ND | |
| IP6K1 | Q92551 | ND | 2 | IP6K2 | Q9UHH9 | ND | 2 | 46.3 | 62.2 | 1019.0 | ND | ND | |
| IP6K3 | Q96PC2 | ND | 2 | IP6K2 | Q9UHH9 | ND | 2 | 44.7 | 58.7 | 911.0 | ND | ND | |
| 3.1.1.3 | AADAC | P22760 | ND | 3 | CEL | B4DSX9 | ND | 3 | 10.3 | 17.7 | 100.5 | ND | ND |
| AADAC | P22760 | ND | 3 | LIPC | P11150 | ND | 4 | 17.1 | 27.6 | 26.0 | ND | ND | |
| AADAC | P22760 | ND | 3 | PNLIP | P16233 | 1LPB | 4 | 13.6 | 24.5 | 18.0 | ND | ND | |
| AADAC | P22760 | ND | 3 | PNLIPRP1 | P54315 | 2PPL | 4 | 11.5 | 20.7 | 25.5 | ND | ND | |
| AADAC | P22760 | ND | 3 | PNLIPRP3 | Q17RR3 | ND | 4 | 13.5 | 22.3 | 36.0 | ND | ND | |
| AADAC | P22760 | ND | 3 | LIPG | Q9Y5X9 | ND | 4 | 11.7 | 22.4 | 15.0 | ND | ND | |
| AADAC | P22760 | ND | 3 | PNLIPRP2 | P54317 | 2OXE | 4 | 14.6 | 26.6 | 36.0 | ND | ND | |
| CEL | B4DSX9 | ND | 3 | LIPC | P11150 | ND | 4 | 10.3 | 15.8 | 41.0 | ND | ND | |
| CEL | B4DSX9 | ND | 3 | PNLIP | P16233 | 1LPB | 4 | 11.8 | 18.7 | 34.0 | ND | ND | |
| CEL | B4DSX9 | ND | 3 | PNLIPRP1 | P54315 | 2PPL | 4 | 5.6 | 8.6 | 29.0 | ND | ND | |
| CEL | B4DSX9 | ND | 3 | PNLIPRP3 | Q17RR3 | ND | 4 | 7.4 | 12.7 | 31.5 | ND | ND | |
| CEL | B4DSX9 | ND | 3 | LIPG | Q9Y5X9 | ND | 4 | 11.5 | 19.2 | 42.5 | ND | ND | |
| CEL | B4DSX9 | ND | 3 | PNLIPRP2 | P54317 | 2OXE | 4 | 4.8 | 8.5 | 21.5 | ND | ND | |
| AADAC | P22760 | ND | 3 | LIPF | P07098 | 1HLG | 9 | 18.2 | 31.1 | 57.0 | ND | ND | |
| CEL | B4DSX9 | ND | 3 | LIPF | P07098 | 1HLG | 9 | 13.5 | 22.3 | 32.0 | ND | ND | |
| AADAC | P22760 | ND | 3 | PNPLA3 | Q9NST1 | ND | 10 | 3.4 | 5.1 | 36.0 | ND | ND | |
| CEL | B4DSX9 | ND | 3 | PNPLA3 | Q9NST1 | ND | 10 | 17.8 | 26.5 | 42.5 | ND | ND | |
| LIPC | P11150 | ND | 4 | PNLIP | P16233 | 1LPB | 4 | 28.4 | 42.1 | 503.0 | ND | ND | |
| LIPC | P11150 | ND | 4 | PNLIPRP1 | P54315 | 2PPL | 4 | 29.0 | 42.3 | 506.0 | ND | ND | |
| LIPC | P11150 | ND | 4 | PNLIPRP3 | Q17RR3 | ND | 4 | 29.5 | 43.9 | 536.0 | ND | ND | |
| LIPC | P11150 | ND | 4 | LIPG | Q9Y5X9 | ND | 4 | 41.3 | 61.0 | 1059.5 | ND | ND | |
| LIPC | P11150 | ND | 4 | PNLIPRP2 | P54317 | 2OXE | 4 | 27.1 | 43.0 | 473.5 | ND | ND | |
| PNLIP | P16233 | 1LPB | 4 | PNLIPRP1 | P54315 | 2PPL | 4 | 67.3 | 80.6 | 1750.0 | 0.93392 | 1.76 | |
| PNLIP | P16233 | 1LPB | 4 | PNLIPRP3 | Q17RR3 | ND | 4 | 47.3 | 63.7 | 1113.5 | ND | ND | |
| PNLIP | P16233 | 1LPB | 4 | LIPG | Q9Y5X9 | ND | 4 | 30.5 | 42.2 | 556.5 | ND | ND | |
| PNLIP | P16233 | 1LPB | 4 | PNLIPRP2 | P54317 | 2OXE | 4 | 64.0 | 79.5 | 1676.0 | 0.94537 | 1.37 | |
| PNLIPRP1 | P54315 | 2PPL | 4 | PNLIPRP3 | Q17RR3 | ND | 4 | 48.4 | 64.3 | 1158.0 | ND | ND | |
| PNLIPRP1 | P54315 | 2PPL | 4 | LIPG | Q9Y5X9 | ND | 4 | 28.5 | 42.5 | 543.5 | ND | ND | |
| PNLIPRP1 | P54315 | 2PPL | 4 | PNLIPRP2 | P54317 | 2OXE | 4 | 62.7 | 77.0 | 1655.0 | 0.92898 | 1.81 | |
| PNLIPRP3 | Q17RR3 | ND | 4 | LIPG | Q9Y5X9 | ND | 4 | 29.3 | 44.2 | 519.0 | ND | ND | |
| PNLIPRP3 | Q17RR3 | ND | 4 | PNLIPRP2 | P54317 | 2OXE | 4 | 47.8 | 62.2 | 1156.5 | ND | ND | |
| LIPG | Q9Y5X9 | ND | 4 | PNLIPRP2 | P54317 | 2OXE | 4 | 28.6 | 44.9 | 536.5 | ND | ND | |
| LIPC | P11150 | ND | 4 | LIPF | P07098 | 1HLG | 9 | 15.9 | 28.2 | 41.0 | ND | ND | |
| PNLIP | P16233 | 1LPB | 4 | LIPF | P07098 | 1HLG | 9 | 17.2 | 26.2 | 65.5 | 0.39307 | 4.45 | |
| PNLIPRP1 | P54315 | 2PPL | 4 | LIPF | P07098 | 1HLG | 9 | 16.8 | 29.2 | 37.0 | 0.38582 | 5.08 | |
| PNLIPRP3 | Q17RR3 | ND | 4 | LIPF | P07098 | 1HLG | 9 | 16.5 | 25.8 | 41.5 | ND | ND | |
| LIPG | Q9Y5X9 | ND | 4 | LIPF | P07098 | 1HLG | 9 | 12.3 | 22.0 | 26.0 | ND | ND | |
| PNLIPRP2 | P54317 | 2OXE | 4 | LIPF | P07098 | 1HLG | 9 | 6.1 | 9.8 | 26.0 | 0.40059 | 5.14 | |
| LIPC | P11150 | ND | 4 | PNPLA3 | Q9NST1 | ND | 10 | 6.9 | 11.9 | 48.5 | ND | ND | |
| PNLIP | P16233 | 1LPB | 4 | PNPLA3 | Q9NST1 | ND | 10 | 11.6 | 18.8 | 31.0 | ND | ND | |
| PNLIPRP1 | P54315 | 2PPL | 4 | PNPLA3 | Q9NST1 | ND | 10 | 14.3 | 21.2 | 54.0 | ND | ND | |
| PNLIPRP3 | Q17RR3 | ND | 4 | PNPLA3 | Q9NST1 | ND | 10 | 9.2 | 16.5 | 34.0 | ND | ND | |
| LIPG | Q9Y5X9 | ND | 4 | PNPLA3 | Q9NST1 | ND | 10 | 7.9 | 12.3 | 30.0 | ND | ND | |
| PNLIPRP2 | P54317 | 2OXE | 4 | PNPLA3 | Q9NST1 | ND | 10 | 13.1 | 20.8 | 38.5 | ND | ND | |
| LIPF | P07098 | 1HLG | 9 | PNPLA3 | Q9NST1 | ND | 10 | 2.5 | 3.5 | 7.0 | ND | ND | |
| 3.1.1.29 | PTRH2 | Q9Y3E5 | 1Q7S | 1 | PTRH1 | Q86Y79 | ND | 2 | 17.6 | 27.5 | 28.0 | ND | ND |
| PTRH2 | Q9Y3E5 | 1Q7S | 1 | ICT1 | Q14197 | ND | 3 | 10.2 | 14.9 | 18.0 | ND | ND | |
| PTRH1 | Q86Y79 | ND | 2 | ICT1 | Q14197 | ND | 3 | 13.3 | 21.8 | 15.5 | ND | ND | |
| 3.1.2.2 | ACOT2 | P49753 | 3HLK | 1 | BAAT | Q14032 | ND | 1 | 38.0 | 51.0 | 873.5 | ND | ND |
| ACOT2 | P49753 | 3HLK | 1 | ACOT1 | Q86TX2 | ND | 1 | 86.1 | 86.5 | 2217.0 | ND | ND | |
| ACOT2 | P49753 | 3HLK | 1 | ACOT4 | Q8N9L9 | 3K2I | 1 | 61.1 | 70.6 | 1601.0 | 0.95168 | 1.20 | |
| BAAT | Q14032 | ND | 1 | ACOT1 | Q86TX2 | ND | 1 | 42.9 | 56.9 | 868.5 | ND | ND | |
| BAAT | Q14032 | ND | 1 | ACOT4 | Q8N9L9 | 3K2I | 1 | 43.1 | 56.7 | 841.0 | ND | ND | |
| ACOT1 | Q86TX2 | ND | 1 | ACOT4 | Q8N9L9 | 3K2I | 1 | 70.3 | 81.0 | 1603.0 | ND | ND | |
| ACOT2 | P49753 | 3HLK | 1 | ACOT7 | O00154 | 2QQ2 | 2 | 2.8 | 4.6 | 27.5 | 0.19192 | 4.25 | |
| BAAT | Q14032 | ND | 1 | ACOT7 | O00154 | 2QQ2 | 2 | 0.4 | 0.8 | 9.0 | ND | ND | |
| ACOT1 | Q86TX2 | ND | 1 | ACOT7 | O00154 | 2QQ2 | 2 | 13.4 | 21.5 | 18.5 | ND | ND | |
| ACOT4 | Q8N9L9 | 3K2I | 1 | ACOT7 | O00154 | 2QQ2 | 2 | 2.0 | 2.5 | 13.5 | 0.23303 | 5.39 | |
| 3.1.3.2 | ACP5 | P13686 | 1WAR | 1 | ACP2 | P11117 | ND | 2 | 4.2 | 7.9 | 23.0 | ND | ND |
| ACP5 | P13686 | 1WAR | 1 | ACPP | P15309 | 1CVI | 2 | 16.6 | 28.3 | 22.5 | 0.38800 | 5.44 | |
| ACP5 | P13686 | 1WAR | 1 | ACPT | Q9BZG2 | ND | 2 | 17.4 | 24.4 | 43.0 | ND | ND | |
| ACP5 | P13686 | 1WAR | 1 | ACP6 | Q9NPH0 | 4JOB | 2 | 15.5 | 24.3 | 19.5 | 0.36502 | 5.59 | |
| ACP5 | P13686 | 1WAR | 1 | ACP1 | P24666 | 5PNT | 5 | 10.1 | 17.0 | 24.5 | 0.34702 | 5.16 | |
| ACP2 | P11117 | ND | 2 | ACPP | P15309 | 1CVI | 2 | 43.6 | 58.4 | 976.5 | ND | ND | |
| ACP2 | P11117 | ND | 2 | ACPT | Q9BZG2 | ND | 2 | 43.0 | 57.2 | 842.5 | ND | ND | |
| ACP2 | P11117 | ND | 2 | ACP6 | Q9NPH0 | 4JOB | 2 | 21.3 | 33.9 | 269.5 | ND | ND | |
| ACPP | P15309 | 1CVI | 2 | ACPT | Q9BZG2 | ND | 2 | 36.8 | 50.2 | 770.0 | ND | ND | |
| ACPP | P15309 | 1CVI | 2 | ACP6 | Q9NPH0 | 4JOB | 2 | 26.1 | 41.5 | 319.5 | 0.80111 | 2.77 | |
| ACPT | Q9BZG2 | ND | 2 | ACP6 | Q9NPH0 | 4JOB | 2 | 24.4 | 35.3 | 289.5 | ND | ND | |
| ACP2 | P11117 | ND | 2 | ACP1 | P24666 | 5PNT | 5 | 8.5 | 13.9 | 28.5 | ND | ND | |
| ACPP | P15309 | 1CVI | 2 | ACP1 | P24666 | 5PNT | 5 | 10.1 | 18.9 | 19.0 | 0.26430 | 5.89 | |
| ACPT | Q9BZG2 | ND | 2 | ACP1 | P24666 | 5PNT | 5 | 6.0 | 12.9 | 13.0 | ND | ND | |
| ACP6 | Q9NPH0 | 4JOB | 2 | ACP1 | P24666 | 5PNT | 5 | 2.2 | 4.1 | 16.5 | 0.24707 | 4.77 | |
| 3.1.3.5 | NT5C1B | Q96P26 | ND | 2 | NT5C1A | Q9BXI3 | ND | 2 | 35.4 | 43.0 | 1145.0 | ND | ND |
| NT5C1B | Q96P26 | ND | 2 | NT5E | P21589 | 4H2G | 3 | 8.5 | 13.3 | 26.0 | ND | ND | |
| NT5C1A | Q9BXI3 | ND | 2 | NT5E | P21589 | 4H2G | 3 | 10.8 | 20.1 | 32.5 | ND | ND | |
| NT5C1B | Q96P26 | ND | 2 | NT5C | Q8TCD5 | 4L57 | 5 | 7.3 | 13.2 | 29.5 | ND | ND | |
| NT5C1B | Q96P26 | ND | 2 | NT5M | Q9NPB1 | 4MUM | 5 | 6.0 | 9.3 | 48.0 | ND | ND | |
| NT5C1A | Q9BXI3 | ND | 2 | NT5C | Q8TCD5 | 4L57 | 5 | 9.7 | 15.1 | 29.0 | ND | ND | |
| NT5C1A | Q9BXI3 | ND | 2 | NT5M | Q9NPB1 | 4MUM | 5 | 8.5 | 14.0 | 26.5 | ND | ND | |
| NT5C1B | Q96P26 | ND | 2 | NT5C3A | Q9H0P0 | 2CN1 | 7 | 8.6 | 16.6 | 35.5 | ND | ND | |
| NT5C1A | Q9BXI3 | ND | 2 | NT5C3A | Q9H0P0 | 2CN1 | 7 | 9.1 | 17.1 | 23.5 | ND | ND | |
| NT5C1B | Q96P26 | ND | 2 | NT5C2 | P49902 | 2XCW | 9 | 8.6 | 13.9 | 42.5 | ND | ND | |
| NT5C1A | Q9BXI3 | ND | 2 | NT5C2 | P49902 | 2XCW | 9 | 8.2 | 14.5 | 20.0 | ND | ND | |
| NT5E | P21589 | 4H2G | 3 | NT5C | Q8TCD5 | 4L57 | 5 | 7.7 | 13.4 | 7.0 | 0.26104 | 5.86 | |
| NT5E | P21589 | 4H2G | 3 | NT5M | Q9NPB1 | 4MUM | 5 | 2.0 | 3.2 | 12.0 | 0.26951 | 5.69 | |
| NT5E | P21589 | 4H2G | 3 | NT5C3A | Q9H0P0 | 2CN1 | 7 | 8.9 | 15.9 | 30.5 | 0.26314 | 5.72 | |
| NT5E | P21589 | 4H2G | 3 | NT5C2 | P49902 | 2XCW | 9 | 15.4 | 26.8 | 36.0 | 0.27774 | 7.25 | |
| NT5C | Q8TCD5 | 4L57 | 5 | NT5M | Q9NPB1 | 4MUM | 5 | 51.3 | 64.7 | 660.0 | 0.96844 | 0.70 | |
| NT5C | Q8TCD5 | 4L57 | 5 | NT5C3A | Q9H0P0 | 2CN1 | 7 | 6.7 | 9.9 | 27.5 | 0.50279 | 4.85 | |
| NT5M | Q9NPB1 | 4MUM | 5 | NT5C3A | Q9H0P0 | 2CN1 | 7 | 14.1 | 26.9 | 40.0 | 0.50929 | 4.86 | |
| NT5C | Q8TCD5 | 4L57 | 5 | NT5C2 | P49902 | 2XCW | 9 | 7.5 | 11.8 | 26.0 | 0.44003 | 3.79 | |
| NT5M | Q9NPB1 | 4MUM | 5 | NT5C2 | P49902 | 2XCW | 9 | 4.6 | 9.1 | 23.5 | 0.44594 | 3.87 | |
| NT5C3A | Q9H0P0 | 2CN1 | 7 | NT5C2 | P49902 | 2XCW | 9 | 8.5 | 14.7 | 46.0 | 0.45164 | 4.71 | |
| 3.1.4.12 | SMPD2 | O60906 | ND | 1 | SMPD3 | Q9NY59 | ND | 1 | 10.4 | 15.2 | 87.5 | ND | ND |
| SMPD2 | O60906 | ND | 1 | SMPD1 | P17405 | 5I81 | 2 | 5.5 | 10.0 | 35.5 | ND | ND | |
| SMPD3 | Q9NY59 | ND | 1 | SMPD1 | P17405 | 5I81 | 2 | 2.6 | 3.6 | 51.0 | ND | ND | |
| SMPD2 | O60906 | ND | 1 | SMPD4 | Q9NXE4 | ND | 3 | 8.2 | 13.6 | 62.0 | ND | ND | |
| SMPD3 | Q9NY59 | ND | 1 | SMPD4 | Q9NXE4 | ND | 3 | 12.7 | 20.2 | 51.5 | ND | ND | |
| SMPD2 | O60906 | ND | 1 | ENPP7 | Q6UWV6 | 5UDY | 4 | 7.0 | 12.8 | 27.5 | ND | ND | |
| SMPD3 | Q9NY59 | ND | 1 | ENPP7 | Q6UWV6 | 5UDY | 4 | 13.3 | 19.2 | 29.5 | ND | ND | |
| SMPD1 | P17405 | 5I81 | 2 | SMPD4 | Q9NXE4 | ND | 3 | 6.3 | 10.7 | 39.0 | ND | ND | |
| SMPD1 | P17405 | 5I81 | 2 | ENPP7 | Q6UWV6 | 5UDY | 4 | 16.1 | 25.0 | 28.5 | 0.28698 | 6.61 | |
| SMPD4 | Q9NXE4 | ND | 3 | ENPP7 | Q6UWV6 | 5UDY | 4 | 5.6 | 8.7 | 49.5 | ND | ND | |
| 4.2.99.18 | NTHL1 | P78549 | ND | 1 | OGG1 | O15527 | 1KO9 | 1 | 19.0 | 28.4 | 85.5 | ND | ND |
| NTHL1 | P78549 | ND | 1 | NEIL2 | Q969S2 | 1VZP | 1 | 14.6 | 25.7 | 29.0 | ND | ND | |
| NTHL1 | P78549 | ND | 1 | NEIL1 | Q96FI4 | 1TDH | 1 | 6.7 | 9.8 | 40.0 | ND | ND | |
| OGG1 | O15527 | 1KO9 | 1 | NEIL2 | Q969S2 | 1VZP | 1 | 2.9 | 4.3 | 24.0 | 0.27899 | 4.84 | |
| OGG1 | O15527 | 1KO9 | 1 | NEIL1 | Q96FI4 | 1TDH | 1 | 14.3 | 20.2 | 42.5 | 0.28166 | 6.65 | |
| NTHL1 | P78549 | ND | 1 | APEX1 | P27695 | 2O3H | 1 | 15.6 | 23.0 | 41.0 | ND | ND | |
| NTHL1 | P78549 | ND | 1 | APEX2 | Q9UBZ4 | ND | 1 | 4.7 | 6.6 | 14.5 | ND | ND | |
| OGG1 | O15527 | 1KO9 | 1 | APEX1 | P27695 | 2O3H | 1 | 16.5 | 26.7 | 23.5 | 0.27998 | 6.74 | |
| OGG1 | O15527 | 1KO9 | 1 | APEX2 | Q9UBZ4 | ND | 1 | 9.4 | 14.6 | 42.5 | ND | ND | |
| NTHL1 | P78549 | ND | 1 | APLF | Q8IW19 | 2KUO | 6 | 3.7 | 6.1 | 24.5 | ND | ND | |
| OGG1 | O15527 | 1KO9 | 1 | APLF | Q8IW19 | 2KUO | 6 | 6.0 | 8.7 | 20.5 | 0.14656 | 6.94 | |
| NEIL2 | Q969S2 | 1VZP | 1 | NEIL1 | Q96FI4 | 1TDH | 1 | 18.8 | 24.9 | 143.5 | 0.50213 | 2.44 | |
| NEIL2 | Q969S2 | 1VZP | 1 | APEX1 | P27695 | 2O3H | 1 | 13.2 | 22.2 | 19.5 | 0.28098 | 4.80 | |
| NEIL2 | Q969S2 | 1VZP | 1 | APEX2 | Q9UBZ4 | ND | 1 | 6.6 | 10.5 | 42.0 | ND | ND | |
| NEIL1 | Q96FI4 | 1TDH | 1 | APEX1 | P27695 | 2O3H | 1 | 5.2 | 7.3 | 44.0 | 0.25323 | 6.80 | |
| NEIL1 | Q96FI4 | 1TDH | 1 | APEX2 | Q9UBZ4 | ND | 1 | 14.6 | 20.8 | 41.0 | ND | ND | |
| NEIL2 | Q969S2 | 1VZP | 1 | APLF | Q8IW19 | 2KUO | 6 | 3.9 | 7.9 | 24.5 | 0.09438 | 5.32 | |
| NEIL1 | Q96FI4 | 1TDH | 1 | APLF | Q8IW19 | 2KUO | 6 | 10.7 | 18.3 | 46.5 | 0.15631 | 6.56 | |
| APEX1 | P27695 | 2O3H | 1 | APEX2 | Q9UBZ4 | ND | 1 | 14.9 | 22.0 | 264.0 | ND | ND | |
| APEX1 | P27695 | 2O3H | 1 | APLF | Q8IW19 | 2KUO | 6 | 6.7 | 12.8 | 47.5 | 0.16022 | 6.62 | |
| APEX2 | Q9UBZ4 | ND | 1 | APLF | Q8IW19 | 2KUO | 6 | 12.3 | 20.5 | 44.5 | ND | ND | |
| 5.3.99.2 | PTGDS | P41222 | 2WWP | 1 | HPGDS | O60760 | 1IYI | 2 | 13.7 | 21.4 | 9.5 | 0.28983 | 5.76 |
| 5.3.99.3 | PTGES2 | Q9H7Z7 | ND | 1 | PTGES | O14684 | 4AL0 | 2 | 0.6 | 0.6 | 18.0 | ND | ND |
a
The 3D model of the human dehydrogenase (UniProt Q9UQ10) was obtained using the crystal structure of a Macaca fascicularis dehydrogenase (PDB 2O48) by comparative modeling.