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. 2017 Aug 11;45(18):e161. doi: 10.1093/nar/gkx708

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Effects of 3′ and 5′ base mismatches on RNA templated DNA end-joining fidelity of PBCV-1 DNA using iLocks. (A) Probe alignment schematics using an RNA template with base A in the central, polymorphic position. Triangle: 3′ OH group; dashed rectangle: bases participating in the invader structure formation. (B) In each iLock group, average number of RCPs was added and ligation fidelity for each iLock was is presented as a percentage within the group. (C) Wild-type KRAS codon 12 (GGT) was genotyped with a complementary and three mismatching (depicted as a lowercase SNP nucleotides in the figure legend) PLPs and iLocks. Average number of RCPs in negative controls was subtracted from all the RCPs counts.