. Author manuscript; available in PMC: 2017 Dec 20.

Published in final edited form as: Biomed Pharmacother. 2017 Jun 7;92:826–835. doi: 10.1016/j.biopha.2017.05.136

Table 1.

Organ and tissue specific function of natriuretic peptides in human body

Brain	Sympathetic nervous system regulation of food intake?
Heart	Water and sodium balance, cardiovascular homeostasis and prevention of cardiac fibrosis
Skeletal muscle	Increase in mitochondrial respiration and fatty acid oxidation
Adipose tissue	Increase in HSL-mediated lipolysis, mitochondrial biogenesis, fatty acid oxidation WAT “browning”, adiponectin release and decrease in leptin release
Pancreas	Increase in glucose stimulated insulin secretion
Kidney	Increase in natriuresis and diuresis and decrease in RAAS activation
Small Intestine	Relaxation of smooth muscle cells and GLP-1 release?
Liver	Unknown function