Table 1.
Preclinical studies of MSC therapy in rotator cuff repair.
| Study | Year | Animal | Repair Model | Cell Type | N MSCs | Delivery Method |
|---|---|---|---|---|---|---|
| Gulotta et al 20 | 2009 | Rat | SST | Allogenic BM-MSCs | 106/animal | Fibrin Glue Carrier |
| Gulotta et al 54 | 2010 | Rat | SST | Allogenic BM-MSCs transduced with MT1-MMP | 106/animal | Fibrin Glue Carrier |
| Gulotta et al 56 | 2011 | Rat | SST | Allogenic BM-MSCs transduced with BMP-13 | 106/animal | Fibrin Glue Carrier |
| Gulotta et al 55 | 2011 | Rat | SST | Allogenic BM-MSCs transduced with SCX | 106/animal | Fibrin Glue Carrier |
| Shen et al 84 | 2012 | Rabbit | SST | Allogenic TDSCs | 6 × 105/animal | Seeded in Silk Collagen scaffold |
| Yokoya et al 59 | 2012 | Rabbit | IST | Autologous BM-MSCs | n/a | Seeded in polyglycolic acid (PGA) sheet |
| Kida et al 57 | 2013 | Rat | SST | Autologous BM-MSCs | n/a | Transosseous drilling |
| Kim et al 60 | 2013 | Rabbit | SST | Autologous BM-MSCs | n/a | Seeded in open-cell polylactic acid (OPLA) scaffold |
| Levy et al 58 | 2013 | Rat | SST | Autologous BM-MSCs | n/a | Transosseous drilling + cannulated nitinol implant |
| Oh et al 73 | 2014 | Rabbit | SSCT | Allogenic ADSCs | 107/animal | Injection into SSC muscle |
| Mora et al 74 | 2014 | Rat | SST | Allogenic ADSCs | 2 × 106/animal | Collagen Carrier |
| Tao et al 83 | 2015 | Rabbit | SST | Allogenic TDSCs | 4 × 106/animal | Fibrin Glue Carrier |
| Park et al 44 | 2015 | Rabbit | SSCT | Human UCB-MSCs | 0.1mL/animal | Ultrasound-guided injection |
| Degen et al 61 | 2016 | Athymic Rat | SST | Human BM-MSCs | 106/animal | Fibrin Glue Carrier |
| Zong et al 62 | 2016 | Athymic Rat | SST | Human BM-MSCs | 106/animal | Fibrin Glue Carrier |
ADSCs: Adipose Derived stem/stromal cells, BMP-13: bone morphogenetic protein-13, IST: Infraspinatus tendon, MSCs: Mesenchymal stem cells, MT1-MMP: membrane type 1 matrix metalloproteinase, N: Number, SCX: Scleraxis, SSCT: subscapularis tendon, SST: Supraspinatus tendon, TDSCs: Tendon Derived stem/stromal cells, UCB: Umbilical Cord Blood.