. Author manuscript; available in PMC: 2018 Sep 1.

Published in final edited form as: Tech Shoulder Elb Surg. 2017 Sep 1;18(3):e6–e14. doi: 10.1097/BTE.0000000000000132

Table 2.

Clinical studies of MSC therapy in rotator cuff repair.

Study	Year	N	Repair Model	Cell Type	N MSCs	Harvested Site	Delivery Method	Time Points
Ellera Gomes et al ⁶⁷	2012	14	Complete RC tears	Autologous BM-MSCs	n/a	Dorsal IC	Injection at the repaired tendon insertion site and bony footprint	12 m
Jo et al ⁶³	2013	124	SST	Autologous BM-MSCs	n/a	Humerus	Multiple channels in the greater tuberosity	24 m
Milano et al ⁶⁴	2013	80	Full-thickness RC tears	BMS	n/a	Humerus	Microfractures of the greater tuberosity	28 m
Hernigou et al ⁶⁸	2014	90	SST	Autogenous BM-MSC	51,000/12mL	Anterior IC	Injection at the repaired tendon insertion site and bony footprint	6 m and 10 years
Taniguchi et al ⁶⁵	2015	111	All-sized + massive RC tears	BMS	n/a	Humerus	Drilling of multiple holes at the footprint	12-14 m
Skoff et al ⁶⁹	2015	10	Revision RCr	Autogenous BM-MSC	n/a	Dorsal IC	Graft Incubation and injection of remaining marrow to the RC construct	24 m
Yoon et al ⁶⁶	2016	75	Massive RC tears	BMS	n/a	Humerus	Drilling of multiple holes at the footprint + Patch (human dermis) graft	12 m

BMS: bone marrow stimulation, BM-MSCs: Bone marrow mesenchymal stem cells, IC: Iliac Crest, m: Month, MSCs: Mesenchymal stem cells, RC: Rotator cuff, RCr: Rotator cuff repair, SST: Supraspinatus tendon.