Table 1.
Cohort characteristics
| No Axillary Surgery (N=282) |
Axillary Surgery (N=1512) |
Total (N=1794) |
p value | |
|---|---|---|---|---|
| Age | <0.0011 | |||
| Mean (SD) | 65.7 (14.2) | 59.9 (13.4) | 60.8 (13.7) | |
| Median (Range) | 65.8 (35.6–93.9) | 59.3 (26.0–91.8) | 60.3 (26.0–93.9) | |
| Baseline BMI | 0.781 | |||
| Mean (SD) | 25.1 (5.6) | 25.0 (5.7) | 25.0 (5.7) | |
| Median (Range) | 24.3 (12.2–52.3) | 24.0 (11.0–57.9) | 24.1 (11.0–57.9) | |
| BMI category | 0.362 | |||
| Underweight | 20 (7.1%) | 133 (8.8%) | 153 (8.6%) | |
| Normal | 138 (49.1%) | 712 (47.2%) | 850 (47.5%) | |
| Overweight | 76 (27.0%) | 399 (26.5%) | 475 (26.6%) | |
| Obese | 30 (10.7%) | 187 (12.4%) | 217 (12.1%) | |
| Morbidly Obese | 17 (6.0%) | 76 (5.0%) | 93 (5.2%) | |
| Missing | 1 | 5 | 6 | |
| Pathologic stage | <0.0012 | |||
| 0 | 192 (68.1%) | 121 (8.0%) | 313 (17.4%) | |
| I | 76 (27.0%) | 769 (50.9%) | 845 (47.1%) | |
| II | 12 (4.3%) | 496 (32.8%) | 508 (28.3%) | |
| III | 2 (0.7%) | 126 (8.3%) | 128 (7.1%) | |
| Breast surgery | <0.0013 | |||
| BCS | 242 (85.8%) | 807 (53.4%) | 1049 (58.5%) | |
| Unilateral mastectomy | 27 (9.6%) | 479 (31.7%) | 506 (28.2%) | |
| Bilateral mastectomy | 13 (4.6%) | 226 (14.9%) | 239 (13.3%) | |
| Axillary surgery | <0.0013 | |||
| None | 282 (100.0%) | 0 (0.0%) | 282 (15.7%) | |
| SLN | 0 (0.0%) | 726 (48.0%) | 726 (40.5%) | |
| ALND | 0 (0.0%) | 786 (52.0%) | 786 (43.8%) | |
| Surgery combination | <0.0013 | |||
| BCS | 242 (85.8%) | 0 (0.0%) | 242 (13.5%) | |
| BCS with SLN | 0 (0.0%) | 450 (29.8%) | 450 (25.1%) | |
| BCS with ALND | 0 (0.0%) | 357 (23.6%) | 357 (19.9%) | |
| Mastectomy | 40 (14.2%) | 0 (0.0%) | 40 (2.2%) | |
| Mastectomy with SLN | 0 (0.0%) | 276 (18.3%) | 276 (15.4%) | |
| Mastectomy with ALND | 0 (0.0%) | 429 (28.4%) | 429 (23.9%) | |
| Neoadjuvant chemotherapy | <0.0013 | |||
| No | 282 (100.0%) | 1454 (96.2%) | 1736 (96.8%) | |
| Yes | 0 (0.0%) | 58 (3.8%) | 58 (3.2%) | |
| Chemotherapy type | <0.0013 | |||
| None | 277 (98.2%) | 998 (66.0%) | 1275 (71.1%) | |
| AC+Taxane | 2 (0.7%) | 250 (16.5%) | 252 (14.0%) | |
| AC without Taxane | 2 (0.7%) | 195 (12.9%) | 197 (11.0%) | |
| Taxane without AC | 0 (0.0%) | 24 (1.6%) | 24 (1.3%) | |
| Other agents | 1 (0.4%) | 45 (3.0%) | 46 (2.6%) | |
| Radiation therapy | <0.0013 | |||
| None | 155 (55.0%) | 621 (41.1%) | 776 (43.3%) | |
| Breast or chest wall only | 124 (44.0%) | 652 (43.1%) | 776 (43.3%) | |
| Nodal (± breast or chest wall) | 3 (1.1%) | 239 (15.8%) | 242 (13.5%) |
1
Wilcoxon rank-sum
2
Cochran Armitage Trend Test
3
Chi-Square