Table 3.
Multivariable analysis of factors associated with BCRL among patients undergoing any axillary surgery (n = 1512).
| Hazard Ratio | Lower 95% CI |
Upper 95% CI |
p-value | |
|---|---|---|---|---|
| Age, per 1 year | 1.00 | 0.992 | 1.017 | 0.51 |
| BMI | ||||
| < 25 | 1.0 (reference) | |||
| 25–34.99 | 1.49 | 1.12 | 1.98 | 0.006 |
| ≥35 | 1.92 | 1.03 | 3.31 | 0.03 |
| Bilateral breast cancer, yes vs no | 1.34 | 0.50 | 2.88 | 0.51 |
| Pathologic stage | ||||
| 0 | 1.0 (reference) | |||
| I | 1.18 | 0.53 | 3.24 | 0.72 |
| II | 1.37 | 0.58 | 3.89 | 0.52 |
| III | 2.08 | 0.79 | 6.37 | 0.17 |
| Breast surgery, mastectomy vs BCS | 1.04 | 0.69 | 1.58 | 0.86 |
| Axillary surgery, ALND vs SLN surgery | 2.69 | 1.88 | 3.92 | <0.001 |
| Radiation therapy | ||||
| None | 1.0 (reference) | |||
| Breast or chest wall only | 1.55 | 0.94 | 2.59 | 0.09 |
| Nodal (± breast or chest wall) | 1.91 | 1.19 | 3.08 | 0.008 |
| Chemotherapy | ||||
| None | 1.0 (reference) | |||
| AC+Taxane | 2.25 | 1.38 | 3.68 | 0.001 |
| AC without Taxane | 1.68 | 1.03 | 2.74 | 0.04 |
| Taxane without AC | 2.65 | 1.07 | 5.76 | 0.02 |
| Other agents | 0.70 | 0.19 | 1.83 | 0.52 |