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. 2017 Sep 11;45(19):11371–11385. doi: 10.1093/nar/gkx788

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Endogenous miRNAs are abundant within the nucleus and exhibit size-dependent nuclear enrichment. (A) MCF10A cells were separated into nuclear and cytoplasmic fractions and subjected to Illumina sequencing. Clean fractionation is indicated by the differential localization of nuclear snoRNAs and snRNAs and cytoplasmic tRNAs. Endogenous, mature miRNAs are both nuclear and cytoplasmic. The y-axis indicates total sequencing read counts and the x-axis, length of the associated small RNA. (B) Shorter (<20 nt) and longer (>23 nt) miRNAs are preferentially enriched within nuclei. (C) Proportion of the nuclear distribution of miR-222 isomiRs of varying size are indicated by box plot.