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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Eur J Med Chem. 2017 Dec 6;143:881–890. doi: 10.1016/j.ejmech.2017.12.014

Figure 5.

Figure 5

Inclusion of the m-chorobenzyl ring of inhibitor 8B in an idealized position superimposed onto the 5T6D structure (green). The aryl ring occupies the same space and Gln 110 and results in the observed conformational change shown in Figure 4.