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. Author manuscript; available in PMC: 2017 Dec 20.
Published in final edited form as: Sci Transl Med. 2016 Nov 2;8(363):363ra149. doi: 10.1126/scitranslmed.aag1974

Fig. 2. Cytokine-induced STAT phosphorylation by rs34536443 genotype in primary human immune cells.

Fig. 2

Percentage of pSTAT+ cells by rs34536443 genotype for CD4+ naïve T cells, CD4+ memory (Mem) T cells, CD8+ naïve T cells, CD8+ memory T cells, CD19+ B cells and CD14+ monocytes (Mono) upon stimulation with (A) IFNα, (B) IFNβ, (C) IL-6 and (D) IL-10. CD14+ monocytes were stimulated with (E) IL-13. CD4+ memory T cells and CD8+ memory T cells were stimulated with (F) IL-12 (top graph) and IL-23 (bottom graph). For each cytokine a schematic of its receptor chains and the TYK2, JAK and STAT molecules that mediate its signaling are shown to the left of the respective graphs. For panels A-E, P-values provided are for a non-additive genetic model. For panels E and F, Wilcoxon matched-pairs rank tests were used. Error bars = ±SEM.