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. 2017 Oct 3;32(1):214–223. doi: 10.1038/leu.2017.275

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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PI3-K signalling upregulates BATF3 in HRS cells. (a) GO analysis of genes regulated by PI3-K signalling in primary HRS cells (GSE12453^{(ref. 31)} or GSE39133^{(ref. 32)} data or both; total of 137 upregulated and 443 downregulated genes) revealed enrichment of several functions including ‘transcription initiation from RNA polymerase II promoter’. (b) Comparison of genes regulated by PI3-K signalling in primary HRS cells with a comprehensive set of TFs revealed the upregulation of 12 TFs and the downregulation of 47 TFs by PI3-K signalling in HRS cells.