Table 1.
Clinical data of tolerant kidney transplant recipients, patients with chronic-rejection and healthy volunteers.
| Patient Data | Healthy Control | Tolerant | Chronic Rejection |
|---|---|---|---|
| Number of patients | 12 | 17 | 32 |
| Male | 10 | 14 | 22 |
| Female | 2 | 3 | 10 |
| Donor (Living/Deceased) | - | (9/8) | (11/21) |
| Age in years [mean (range)] | 48.0 (23-72) | 50.2 (22-77) | 44.3 (18-72) |
| Recipient age at Transpl [mean (range)] | - | 31.3 (11-56) | 34.9 (11-62) |
| Years immunosuppression free [mean (range)] | - | 6.1 (1-23) | - |
| HLA mismatches per group | |||
| Number of patients with no mismatches | - | 6 | 0 |
| Number of patients with HLA (A or B) mismatches | - | 2 | 2 |
| Number of patients with HLA (A and B) mismatches | - | 1 | 7 |
| Number of patients with HLA (A + DR) mismatches | - | 0 | 3 |
| Number of patients with HLA (B + DR) mismatches | - | 0 | 3 |
| Number of patients with HLA (A, B, DR) mismatches | - | 7 | 14 |
| Missing data | - | 1 | 3 |
| Immunosuppressive Regime | |||
| CNI | - | - | 1 |
| MMF | - | - | 1 |
| CNI + MMF | - | - | 6 |
| CNI + Aza | - | - | 2 |
| CNI + Steroid | - | - | 4 |
| MMF + Steroids | - | - | 1 |
| CNI + MMF + Steroids | - | - | 14 |
| CNI + Aza + Steroids | - | - | 3 |
| Donor-specific antibodies | |||
| No DSA | - | 14 | 16 |
| DSA Class I | - | 2 | 6 |
| DSA Class II | - | 1 | 4 |
| DSA Class I and II | - | 0 | 5 |
| Missing data | 0 | 1 | |
| Renal Function Parameters | |||
| Creatinine (mmols/L) [mean±SD] | - | 116.4±38.5 | 224.9±92.1 |
| eGFR (mL/min/1.73m2) [mean±SD] | - | 64.9±20.1 | 32.8±14.1 |
| Cell Count | |||
| Lymphocytes count x 109 [mean±SD] | 2.18±0.4 | 2.07±1.2 | 1.42±0.9 |
CNI, Calcineurin inhibitor (Cyclosporine or Tacrolimus). Aza, azathioprine. MMF, mycophenolate mofetil. DSA: donor-specific antibodies. eGFR: estimated glomerular filtration rate. SD: standard deviation.