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. Author manuscript; available in PMC: 2018 May 4.
Published in final edited form as: Cell. 2017 May 4;169(4):750–765.e17. doi: 10.1016/j.cell.2017.04.014

Figure 6. CD141+ DC are excluded from lung tumors and immune signature of lung adenocarcinoma tumors.

Figure 6

(A, B) Comparison of the average transcript expression between DC clusters (Figure 4A, clusters 2 and 4), showing highly expressed transcripts in these clusters, genes with FC > 2 colored red (A), and bar plots showing expression of indicated transcripts (B).

(C) Bar plots of DC metacluster frequencies across tissue (Figure 4C; n=18; *p<0.05, **p<0.01 and ***p<0.001 by paired t-test).

(D) MICSSS for CD3 and DC-LAMP showing a TLS at the tumor margin in a representative patient.

(E) MARS-seq transcript levels normalized across mononuclear phagocyte clusters (Figure 4A).

(F) Heatmap showing the relative differences in metacluster frequency between tumor and nLung across 16 patients, grouped by stage.

(G) Bar plots showing neutrophil metacluster frequency and secreted soluble TNFα (pg/ml) at thetumor, stratified by stage (*p<0.05 by unpaired t-test).

Bar plots show mean ± SEM.

See also Figure S6.