Table 2.
Summary of adherence rates for exam elements by study phase
| Phase I N (%) |
Phase II N (%) |
Overall N (%) |
p-value | 95% CIsd | ||
|---|---|---|---|---|---|---|
| All Sites, Total Number Cases | 274 | 280 | 554 | |||
|
| ||||||
| Visual Function | 250 (91.2) | 269 (96.1) | 519 (93.7) | 0.02 b | −1.3, 10.9 | |
| Ocular History | 273 (99.6) | 280 (100.0) | 553 (99.8) | 0.49 c | −1.4, 2.2 | |
| Visual Acuity | 274 (100.0) | 280 (100.0) | 554 (100.0) | ----- | −1.5, 1.5 | |
| Pupil Exam | 273 (99.6) | 280 (100.0) | 553 (99.8) | 0.49 c | −1.4, 2.2 | |
| Anterior Segment Exam | 274 (l00.0) | 280 (100.0) | 554 (100.0) | ----- | −1.5, 1.5 | |
| Intraocular Pressure | 274 (100.0) | 280 (100.0) | 554 (100.0) | ----- | −1.5, 1.5 | |
| All Sites, Positive Responsesa | Gonioscopy | 264 (96.4) | 267 (95.4) | 531 (95.8) | 0.56 b | −6.0, 4.1 |
| Optic Nerve Head/Retinal Nerve Fiber Layer | 274 (l00.0) | 280 (100.0) | 554 (100.0) | ----- | −1.5, 1.5 | |
| Fundus Exam | 274 (100.0) | 280 (100.0) | 554 (100.0) | ----- | −1.5, 1.5 | |
| Corneal Thickness | 256 (93.4) | 267 (95.4) | 523 (94.4) | 0.32 b | −3.9, 7.7 | |
| Visual Field | 271 (98.9) | 270 (96.4) | 541 (97.7) | 0.05 b | −6.4, 1.5 | |
| Target Pressure | 202 (73.7) | 233 (83.2) | 435 (78.5) | 0.01 b | −0.6, 19.5 | |
| Treatment Plan | 274 (100.0) | 280 (100.0) | 554 (100.0) | ----- | −1.5, 1.5 | |
|
| ||||||
| Site A, Total Number Cases | 143 | 202 | 345 | |||
|
| ||||||
| Visual Function | 119 (83.2) | 191 (94.6) | 310 (89.9) | 0.0006 b * | 1.1, 21.6 | |
| Ocular History | 142 (99.3) | 202 (100.0) | 344 (99.7) | 0.41 c | −2.2, 4.0 | |
| Visual Acuity | 143 (100.0) | 202 (100.0) | 345 (100.0) | ----- | −2.2, 2.6 | |
| Pupil Exam | 142 (99.3) | 202 (100.0) | 344 (99.7) | 0.41 c | −2.2, 4.0 | |
| Anterior Segment Exam | 143 (100.0) | 202 (100.0) | 345 (100.0) | ----- | −2.2, 2.6 | |
| Intraocular Pressure | 143 (100.0) | 202 (100.0) | 345 (100.0) | ----- | −2.2, 2.6 | |
| Site A, Positive Responsesa | Gonioscopy | 138 (96.5) | 194 (96.0) | 332 (96.2) | 0.82 b | −6.6, 6.1 |
| Optic Nerve Head/Retinal Nerve Fiber Layer | 143 (100.0) | 202 (100.0) | 345 (100.0) | ----- | −2.2, 2.6 | |
| Fundus Exam | 143 (100.0) | 202 (100.0) | 345 (100.0) | ----- | −2.2, 2.6 | |
| Corneal Thickness | 139 (97.2) | 192 (95.0) | 331 (95.9) | 0.32 b | −8.3, 4.4 | |
| Visual Field | 141 (98.6) | 197 (97.5) | 338 (98.0) | 0.70 c | −5.7, 4.0 | |
| Target Pressure | 102 (71.3) | 163 (80.7) | 265 (76.8) | 0.04 b | −4.2, 22.9 | |
| Treatment Plan | 143 (100.0) | 202 (100.0) | 345 (100.0) | ----- | −2.2, 2.6 | |
|
| ||||||
| Site B, Total Number Cases | 81 | 39 | 120 | |||
|
| ||||||
| Visual Function | 81 (100.0) | 39 (100.0) | 120 (100.0) | ----- | −9.0, 6.5 | |
| Ocular History | 81 (100.0) | 39 (100.0) | 120 (100.0) | ----- | −9.0, 6.5 | |
| Visual Acuity | 81 (100.0) | 39 (100.0) | 120 (100.0) | ----- | −9.0, 6.5 | |
| Pupil Exam | 81 (100.0) | 39 (100.0) | 120 (100.0) | ----- | −9.0, 6.5 | |
| Anterior Segment Exam | 81 (100.0) | 39 (100.0) | 120 (100.0) | ----- | −9.0, 6.5 | |
| Intraocular Pressure | 81 (100.0) | 39 (100.0) | 120 (100.0) | ----- | −9.0, 6.5 | |
| Site B, Positive Responsesa | Gonioscopy | 76 (93.8) | 34 (87.2) | 110 (91.7) | 0.29 c | −25.4, 10.5 |
| Optic Nerve Head/Retinal Nerve Fiber Layer | 81 (100.0) | 39 (100.0) | 120 (100.0) | ----- | −9.0, 6.5 | |
| Fundus Exam | 81 (100.0) | 39 (100.0) | 120 (100.0) | ----- | −9.0, 6.5 | |
| Corneal Thickness | 67 (82.7) | 36 (92.3) | 103 (85.8) | 0.16 b | −9.8, 26.4 | |
| Visual Field | 80 (98.8) | 34 (87.2) | 114 (95.0) | 0.01 c | −28.9, 4.5 | |
| Target Pressure | 50 (61.7) | 31 (79.5) | 81 (67.5) | 0.05 b | −7.6, 40.8 | |
| Treatment Plan | 81 (100.0) | 39 (100.0) | 120 (100.0) | ----- | −9.0, 6.5 | |
|
| ||||||
| Site C, Total Number Cases | 50 | 39 | 89 | |||
|
| ||||||
| Site C, Positive Responsesa | Visual Function | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 |
| Ocular History | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Visual Acuity | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Pupil Exam | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Anterior Segment Exam | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Intraocular Pressure | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Gonioscopy | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Optic Nerve Head/Retinal Nerve Fiber Layer | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Fundus Exam | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Corneal Thickness | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Visual Field | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Target Pressure | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
| Treatment Plan | 50 (100.0) | 39 (100.0) | 89 (100.0) | ----- | −9.4, 8.4 | |
Abbreviation, CI: confidence interval
a
‘Positive Responses’ refer to cases where the required information was presented, or if not, a reasonable explanation was provided for missing information (e.g. visual field test not performed because patient brought most recent visual field results from other doctor’s office)
b
Chi-square test
c
Fisher exact test
d
Bonferroni corrected simultaneous Agresti-Caffo CIs for the difference in adherence rates
*
Statistically significant after accounting for multiple comparisons using the Bonferroni correction (critical p-value = 0.05/13 = 0.004)