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. 2017 Dec 20;12(12):e0188309. doi: 10.1371/journal.pone.0188309

Table 4. Biochemical primary reasons for dialysis initiation in 446 patients as stated by prescribing physicians (n = 84) and how these reasons relate to the corresponding measurements in presence or absence of stating these reasons as a cause to start dialysis.

Term Present Absent P
No. Mean ±SD Median (IQ range) No. Mean ±SD Median (IQ range)
High creatinine (μM) 30 781 ±333 707 (545–947) 282 675 ±343 635 (495–790) (0.06)
(corresponding eGFR (ml/min/1.73 m2)) 6.5 ±3.3 5.6 (4.3–8.4) 7.2 ±3.5 6.6 (5.0–8.7) NS
Low eGFR (ml/min/1.73 m2) 51 6.1 ±2.1 5.9 (4.8–7.4) 251 7.6 ±3,7 6.9 (5.1–9.4) <0.01
(corresponding creatinine (μM)) 719 ±258 669 (576–825) 678 ±317 627 (575–825) NS
Falling eGFR (ml/min/1.73 m2/yr 11 9.2 (2.4–47.6) 238 11.7 (4.3–22.5) NS
High urea (mM) 30 42.2 ±15.6 39.6 (33.0–49.2 298 32.0 ±11.2 29.5 (24.9–38.5) <0.001
High potassium (mM) 22 5.7 ±1.3 6.0 (4.5–6.5) 364 4.3 ±0.7 4.3 (3.9–4.8) <0.001
Acidosis (mM) 10 16.0 ±8.7 13.6 (10–19) 305 21.7 ±4.9 22 (18–25) <0.001
Low calcium* 15 0.96 ±0.11 0.96 (0.86–1.02) 402 1.14 ±0.12 1.15 (1.08–1.22) <0.001
High phosphate* 44 2.17 ±0.57 2.04 (1.83–2.33) 367 1.97 ±0.55 1.92 (1.56–2.30) <0.05

*primary, secondary and other reasons combined.