Table 1. Baseline characteristics of patients with CHA2DS2-VASc score ≥ 2 in 2015 (n = 230,332).
| No OAC, total (n = 113,851) |
No therapy (n = 41,375) |
Aspirin (n = 72,476) |
OAC, total (n = 116,481) |
VKA (n = 57,950) |
NOAC (n = 58,531) |
|
|---|---|---|---|---|---|---|
| Age (mean ± SD) | 72.1±11.2 | 72.3±11.8 | 72.0±10.8 | 72.4±9.8 | 71.7±10.3 | 73.1±9.1 |
| Age 65–74, n (%) | 36,891 (32.4) | 12,455 (30.1) | 24,436 (33.7) | 41,305 (35.5) | 20,190 (34.8) | 21,115 (36.1) |
| Age ≥ 75 years, n (%) | 52,087 (45.8) | 19,837 (47.9) | 32,250 (44.5) | 54,017 (46.4) | 25,645 (44.3) | 28,372 (48.5) |
| Female, n (%) | 57,479 (50.9) | 23,177 (56.0) | 34,302 (47.3) | 53,036 (45.5) | 25,633 (44.2) | 27,403 (46.8) |
| Hypertension, n (%) | 82,251 (72.2) | 26,875 (64.9) | 55,376 (76.4) | 87,257 (74.9) | 42,976 (74.2) | 44,281 (75.7) |
| Diabetes mellitus, n (%) | 29,801 (26.2) | 10,097 (24.4) | 19,704 (21.2) | 33,861 (29.1) | 16,764 (28.9) | 17,097 (29.2) |
| Heart failure, n (%) | 43,441 (38.2) | 13,881 (33.6) | 29,560 (40.8) | 53,287 (45.8) | 26,570 (45.8) | 26,717 (45.7) |
| Prior stroke/TIA/TE, n (%) | 24,579 (21.6) | 9,617 (23.2) | 14,962 (20.6) | 47,852 (41.1) | 21,393 (36.9) | 26,459 (45.2) |
| Stroke, n (%) | 18.993 (16.7) | 7,907 (19.1) | 11,086 (15.3) | 40,868 (35.1) | 17,776 (30.7) | 23,092 (39.5) |
| TIA, n (%) | 3,498 (3.1) | 1,103 (2.7) | 2,395 (3.3) | 4,330 (3.7) | 1,750 (3.0) | 2,580 (4.4) |
| TE, n (%) | 4,037 (3.6) | 1,206 (2.9) | 2,831 (3.9) | 7,616 (6.5) | 3,778 (6.5) | 3,838 (6.6) |
| Vascular disease, n (%) | 30,225 (26.5) | 10,560 (25.5) | 19,665 (27.1) | 20,855 (17.9) | 10,008 (17.3) | 10,847 (18.5) |
| Prior MI, n (%) | 6,952 (6.1) | 1,861 (4.5) | 5,091 (7.0) | 5,352 (4.6) | 2,662 (4.6) | 2,690 (4.6) |
| PAD, n (%) | 24,786 (21.8) | 9,089 (21.9) | 15,697 (21.7) | 16,429 (14.1) | 7,800 (13.5) | 8,629 (14.7) |
| Prior ICH | 3,146 (2.8) | 1,511 (3.6) | 1,635 (2.3) | 3,250 (2.8) | 1,436 (2.5) | 1,814 (3.1) |
| CHA2DS2-VASc score (mean ± SD) | 3.8±1.5 | 3.7±1.5 | 3.8±1.5 | 4.2±1.5 | 4.0±1.5 | 4.3±1.5 |
| CHA2DS2-VASc score, n (%) | ||||||
| Score = 2 | 27,682 (24.3) | 10,140 (24.5) | 17,542 (24.2) | 18,380 (15.8) | 10,810 (18.7) | 7,570 (12.9) |
| Score = 3 | 27,921 (24.5) | 10,410 (25.2) | 17,511 (24.2) | 25,329 (21.8) | 13,225 (22.8) | 12,104 (20.7) |
| Score = 4 | 24,913 (21.9) | 9,033 (21.8) | 15,880 (21.9) | 26,993 (23.2) | 13,360 (23.1) | 13,633 (23.3) |
| Score = 5 | 18,217 (16.0) | 6,685 (16.2) | 11,532 (15.9) | 22,481(19.3) | 10,500(18.1) | 11,981 (20.5) |
| Score = 6 | 9,368 (8.2) | 3,271(7.91) | 6097(8.41) | 14067(12.08) | 6243(10.77) | 7824(13.37) |
| Score = 7 | 4,177 (3.7) | 1,382(3.34) | 2795(3.86) | 6800(5.84) | 2823(4.87) | 3977(6.79) |
| Score = 8 | 1,349 (1.2) | 388(0.94) | 961(1.33) | 2106(1.81) | 857(1.48) | 1249(2.13) |
| Score = 9 | 224 (0.2) | 66(0.16) | 158(0.22) | 325(0.28) | 132(0.23) | 193(0.33) |
Abbreviation: ICH, intracranial hemorrhage; MI, myocardial infarction; NOAC, non-vitamin K antagonist oral anticoagulants; OAC, oral anticoagulants; PAD, peripheral artery disease; SD, standard deviation; TE, thromboembolism, TIA, transient ischemic attack.