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. 2017 Dec 20;12(12):e0190074. doi: 10.1371/journal.pone.0190074

Fig 3. Colon tissue damage in DSS-induced colitis in mice lacking myeloid HIF-1α.

Fig 3

H&E staining (A) and histology scoring (B) of paraffin-embedded colon sections from wild type (HIF-1α+f/+f) and knockout (Lyz2-Cre/HIF-1α+f/+f) mice treated for four to six days (4d-6d) with 2.5% DSS. (C) Real time PCR of Lipocalin-2 in colon RNA samples of wild type (HIF-1α+f/+f) and knockout (Lyz2-Cre/HIF-1α+f/+f) mice treated as in (A). Data are representative for experiments with five or six mice/group. Each time point represents the mean value ± SEM. *P < 0.05; **P < 0.01 and ***P < 0.001 compared as indicated. # displays significance to respective control. Original bars, 50 μm.