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. 2017 Dec 20;12(12):e0190074. doi: 10.1371/journal.pone.0190074

Fig 6. Expression of cytokine mRNA during DSS-treatment in mice without myeloid HIF-1α.

Fig 6

Real time PCR of IL-10 (A), TNFα (B), IFNγ (C), IL-6 (D) and IL-23 (E) in colon RNA samples of wild type (HIF-1α+f/+f) and knockout (Lyz2-Cre/HIF-1α+f/+f) mice treated for four to six days (4d-6d) with 2.5% DSS. Data are representative for experiments with five or six mice/group. (F) Real time PCR of TNFα, IL-1ß, IL-6, IL-10, and IL-17A in RNA samples of bone marrow derived macrophages from wild type (HIF-1α+f/+f) and knockout (Lyz2-Cre/HIF-1α+f/+f) mice treated for six hours with 1% O2. Each time point represents the mean value ± SEM. *P < 0.05; **P < 0.01 and ***P < 0.001 compared as indicated. # displays significance to respective control.