Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 19;11:142. doi: 10.1186/s12918-017-0521-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 4 — Connecting the exposome to the readout of the genome. Given that most major human diseases are genetically complex is it necessary to characterize the extrinsic (environmental) exposures (exposome) and ingestion nutrients (acting through the microbiome) each capable of producing epigenomic modifications that alter the transcriptions in multiple visceral organs and CNS or the gastrointestinal tract (microbiome, innate immune signaling and afferent activation of enteric nervous system). “Figure reprinted from Cell, Volume 157, Issue 1, / Eric J. Topol, Individualized Medicine from Womb to Tomb, Pages 241-253, 2014, with permission from Elsevier” [127]